(Q24337727)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

GOA release 2020-03-11

author

Richard M. Epand

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

author name string

Randy Singh Atwal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Jianrun Xia

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Deborah Pinchev

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Jillian Taylor

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Ray Truant

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

language of work or name

English

0 references

publication date

18 August 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

issue

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

page(s)

2600-2615

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis

3 January 2020

cites work

1 reference

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Recent insights into the molecular pathogenesis of Huntington disease

21 January 2018

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Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

21 January 2018

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

21 January 2018

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Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease

21 January 2018

1 reference

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Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

21 January 2018

1 reference

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Wild-type huntingtin plays a role in brain development and neuronal survival

21 January 2018

1 reference

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Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation

21 January 2018

1 reference

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

1 reference

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Huntingtin contains a highly conserved nuclear export signal

21 January 2018

1 reference

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Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease

21 January 2018

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

21 January 2018

1 reference

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

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SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

1 reference

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Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Monoclonal antibodies from three new regions of huntingtin, the Huntington's disease protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

HEAT repeats in the Huntington's disease protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

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Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Rab7: a key to lysosome biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Detection of autophagy in tissue by standard immunohistochemistry: possibilities and limitations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

LC3 conjugation system in mammalian autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Comparison of ARM and HEAT protein repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Endoplasmic reticulum stress in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Flanking sequences profoundly alter polyglutamine toxicity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

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Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Autophagosome-like vacuole formation in Huntington's disease lymphoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Mouse Models of Triplet Repeat Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

Gain of glutamines, gain of function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

7 January 2021

Neuropathological classification of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

7 January 2021

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

7 January 2021

Live-cell nucleocytoplasmic protein shuttle assay utilizing laser confocal microscopy and FRAP

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

7 January 2021

Computer-assisted image analysis protocol that quantitatively measures subnuclear protein organization in cell populations

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM217

7 January 2021

Identifiers

DOI

10.1093/HMG/DDM217

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17704510%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017