(Q28510315)

English

Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro

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scholarly article

1 reference

25 January 2017

Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro (English)

1 reference

25 January 2017

Huntington's disease

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1 reference

GOA release 2020-03-11

cellular senescence

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based on heuristic

inferred from title

author name string

Erin B. D. Clabough

1

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25 January 2017

Scott O. Zeitlin

2

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25 January 2017

publication date

15 February 2006

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25 January 2017

Human Molecular Genetics

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25 January 2017

15

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25 January 2017

4

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25 January 2017

607–623

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25 January 2017

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Glutamine repeats and neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin contains a highly conserved nuclear export signal

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Inactivation of the mouse Huntington's disease gene homolog Hdh

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin: a single bait hooks many species

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

The hunt for huntingtin function: interaction partners tell many different stories

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

SUMO modification of Huntingtin and Huntington's disease pathology

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin associates with acidic phospholipids at the plasma membrane

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

HEAT repeats in the Huntington's disease protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Comparative sequence analysis of the human and pufferfish Huntington's disease genes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Characterization of the Huntington's disease (HD) gene homologue in the zebrafish Danio rerio.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

A putative Drosophila homolog of the Huntington's disease gene

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Hprt(CAG)146 mice: age of onset of behavioral abnormalities, time course of neuronal intranuclear inclusion accumulation, neurotransmitter marker alterations, mitochondrial function markers, and susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydro

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

The signals and pathways activating cellular senescence

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Increased expression of the Huntingtin interacting protein-1 gene in cells from Hutchinson Gilford Syndrome (Progeria) patients and aged donors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Lipofuscin pigment accumulation in the central nervous system of the mouse during aging.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Lipofuscin pigment accumulation in human brain during aging.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Trinucleotide repeats in neurologic diseases: an hypothesis concerning the pathogenesis of Huntington's disease, Kennedy's disease, and spinocerebellar ataxia type I.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

The N-terminal TPR region is the functional domain of SSN6, a nuclear phosphoprotein of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

The DAL81 gene product is required for induced expression of two differently regulated nitrogen catabolic genes in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Pharmacologic and behavioral responses of inbred C57BL/6J and strain 129/SvJ mouse lines

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Motor learning in Ts65Dn mice, a model for Down syndrome.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Biochemical characterizations reveal different properties between CDK4/cyclin D1 and CDK2/cyclin A.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI477

21 January 2018

Identifiers

10.1093/HMG/DDI477

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1 reference

25 January 2017

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