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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
title
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
(English)
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
main subject
brain
0 references
Huntingtin
1 reference
stated in
GOA release 2020-03-11
author name string
I. Dragatsis
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
M. S. Levine
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
S. Zeitlin
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
language of work or name
English
0 references
publication date
1 November 2000
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
published in
Nature Genetics
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
volume
26
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
page(s)
300–306
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stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
issue
3
1 reference
stated in
PubMed
PubMed ID
11062468
retrieved
1 February 2017
cites work
Recent advances in understanding the pathogenesis of Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntington's disease gene (IT15) is widely expressed in human and rat tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
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7 January 2021
based on heuristic
inferred from DOI database lookup
Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Widespread expression of Huntington's disease gene (IT15) protein product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntington's disease: translating a CAG repeat into a pathogenic mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the mouse Huntington's disease gene homolog Hdh
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Subregion- and cell type-restricted gene knockout in mouse brain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Motor abnormalities in weaver mutant mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo hypoxia-induced neuronal damage with an enhancement of neuronal nitric oxide synthase immunoreactivity in hippocampus.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early effects of intrastriatal injections of quinolinic acid on microtubule-associated protein-2 and neuropeptides in rat basal ganglia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct roles for adhesion molecules during innervation of embryonic chick muscle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Life without huntingtin: normal differentiation into functional neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fast transport and retrograde movement of huntingtin and HAP 1 in axons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A molecular investigation of true dominance in Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disassembly of nuclear inclusions in the dividing cell--a novel insight into neurodegeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formation of polyglutamine inclusions in non-CNS tissue
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type huntingtin protects from apoptosis upstream of caspase-3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F81593
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/81593
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1482023
OpenCitations bibliographic resource ID
1482023
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1482023
PubMed ID
11062468
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1482023
ResearchGate publication ID
12265394
0 references
Springer Nature article ID
10.1038/81593
0 references
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