(Q45298582)

English

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

scientific article published in May 1999

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

Huntington's disease

0 references

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

Michael R. Hayden

19

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

Roshni Singaraja

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

14

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Europe PubMed Central

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10 December 2019

author name string

J G Hodgson

1

1 reference

Europe PubMed Central

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10 December 2019

N Agopyan

2

1 reference

Europe PubMed Central

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10 December 2019

C A Gutekunst

3

1 reference

Europe PubMed Central

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10 December 2019

B R Leavitt

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

F LePiane

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

D J Smith

7

1 reference

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10 December 2019

N Bissada

8

1 reference

Europe PubMed Central

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10 December 2019

K McCutcheon

9

1 reference

Europe PubMed Central

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10 December 2019

J Nasir

10

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

L Jamot

11

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Europe PubMed Central

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10 December 2019

X J Li

12

1 reference

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10 December 2019

M E Stevens

13

1 reference

Europe PubMed Central

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10 December 2019

J C Roder

15

1 reference

Europe PubMed Central

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10 December 2019

A G Phillips

16

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

E M Rubin

17

1 reference

Europe PubMed Central

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10 December 2019

S M Hersch

18

1 reference

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10 December 2019

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publication date

1 May 1999

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10 December 2019

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

23

1 reference

Europe PubMed Central

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10 December 2019

1

1 reference

Europe PubMed Central

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10 December 2019

181-192

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10402204%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

Alternative excitotoxic hypotheses

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Dentatorubral and pallidoluysian atrophy (DRPLA) Clinical and neuropathological findings in genetically confirmed north american and european pedigrees

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of the mouse Huntington's disease gene homolog Hdh

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective sparing of a class of striatal neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A huntingtin-associated protein enriched in brain with implications for pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuropathological classification of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980764-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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