(Q42845671)

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Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

scientific article published on October 2010

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14 January 2020

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A (English)

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14 January 2020

phosphorylation

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Michael R. Hayden

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14 January 2020

Blair R Leavitt

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Blair R Leavitt

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14 January 2020

Martina Metzler

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Martina Metzler

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14 January 2020

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Rona K Graham

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14 January 2020

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Nagat Bissada

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14 January 2020

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Lu Gan

2

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14 January 2020

Gelareh Mazarei

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14 January 2020

Lili Liu

5

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14 January 2020

Ge Lu

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14 January 2020

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1 October 2010

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14 January 2020

Journal of Neuroscience

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14 January 2020

30

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14 January 2020

43

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14 January 2020

14318-14329

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14 January 2020

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington's disease: a clinical, genetic and molecular model for polyglutamine repeat disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent NMDA receptor-mediated activation of protein kinase B/Akt in cortical neuronal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DARPP-32: an integrator of neurotransmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatases and their potential implications in neuroprotective processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A positive feedback loop between glycogen synthase kinase 3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type huntingtin protects neurons from excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional and cellular gene expression changes in human Huntington's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin inhibits caspase-3 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated deformation analysis in the YAC128 Huntington disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glucose tolerance in the R6/1 transgenic mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse models of Huntington disease: variations on a theme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA and D1 receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional regulation of DARPP-32 phosphorylation by dopamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20980587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1589-10.2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20980587%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20980587%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20980587%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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