(Q40020558)

16 September 2017

title

Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells (English)

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16 September 2017

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4

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16 September 2017

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Xavier Xifró

1

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16 September 2017

Juan Manuel García-Martínez

series ordinal

2

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16 September 2017

Daniel Del Toro

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3

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16 September 2017

Esther Pérez-Navarro

series ordinal

5

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16 September 2017

language of work or name

English

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publication date

24 January 2008

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Journal of Neurochemistry

16 September 2017

published in

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16 September 2017

volume

105

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16 September 2017

issue

5

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16 September 2017

page(s)

1596-1612

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FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

16 September 2017

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High level calcineurin activity predisposes neuronal cells to apoptosis

21 January 2018

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Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

21 January 2018

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Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

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Deranged neuronal calcium signaling and Huntington disease.

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The death-associated protein kinases: structure, function, and beyond

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Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain.

21 January 2018

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Inhibition of protein phosphatase 2B upregulates serine phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in striatal neurons in vivo

21 January 2018

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

21 January 2018

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Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

21 January 2018

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Excitotoxic injury of the neostriatum: a model for Huntington's disease

21 January 2018

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N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

21 January 2018

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Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia

21 January 2018

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Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

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Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

21 January 2018

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Immortalized GABAergic cell lines derived from rat striatum using a temperature-sensitive allele of the SV40 large T antigen.

21 January 2018

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Brain-derived neurotrophic factor (BDNF) mediates bone morphogenetic protein-2 (BMP-2) effects on cultured striatal neurones

21 January 2018

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Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

21 January 2018

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The biochemistry of apoptosis

21 January 2018

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Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation

21 January 2018

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Calpains (intracellular calcium-activated cysteine proteinases): structure-activity relationships and involvement in normal and abnormal cellular metabolism

21 January 2018

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Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6/2 Huntington's disease transgenic mice

21 January 2018

1 reference

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

21 January 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

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NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1

21 January 2018

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Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences

21 January 2018

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Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells

21 January 2018

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Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

21 January 2018

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Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A

21 January 2018

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Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Brief exposure to NMDA produces long-term protection of cerebellar granule cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Calcineurin-mediated BAD Ser155 dephosphorylation in ammonia-induced apoptosis of cultured rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05252.X

10.1111/J.1471-4159.2008.05252.X

21 January 2018

Identifiers

DOI

1 reference

16 September 2017

1 reference