(Q45299979)

English

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

scientific article published in February 2006

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scholarly article

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16 January 2020

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421 (English)

1 reference

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16 January 2020

phosphorylation

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based on heuristic

inferred from title

5

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16 January 2020

Sandrine Humbert

6

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16 January 2020

Frédéric Saudou

7

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16 January 2020

author name string

Raúl Pardo

1

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16 January 2020

Emilie Colin

2

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16 January 2020

Etienne Régulier

3

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16 January 2020

Patrick Aebischer

4

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16 January 2020

language of work or name

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publication date

1 February 2006

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16 January 2020

Journal of Neuroscience

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16 January 2020

26

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16 January 2020

5

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16 January 2020

1635-1645

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16 January 2020

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin is required for skeletal muscle hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of the distribution of calmodulin kinase II and calcineurin in the mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin: from structure to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin: form and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain activation in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin fragments that aggregate go their separate ways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From calcium to NF-kappa B signaling pathways in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional abnormalities in Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FK506 and its analogs - therapeutic potential for neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cell death: the calcium-apoptosis link

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular actions of calcineurin inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of FK506 (tacrolimus) in pentylenetetrazol-induced kindling in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin in memory and bidirectional plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K/Akt and apoptosis: size matters

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin: a central controller of signalling in eukaryotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO modification of Huntingtin and Huntington's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deranged neuronal calcium signaling and Huntington disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt is altered in an animal model of Huntington's disease and in patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal transport failure in neurodegenerative disorders: the case of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunohistochemical investigation of the human neostriatum in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein serine/threonine phosphatases--new avenues for cell regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington's disease: CAG genetics expands neurobiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural actions of immunophilin ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16452687

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3706-05.2006

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16452687%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16452687%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16452687%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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