(Q44495460)

English

Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.

scientific article published in June 2003

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scholarly article

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Europe PubMed Central

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5 November 2019

Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12832525%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Huntington's disease

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Emmanuel Brouillet

10

1 reference

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5 November 2019

Jean-Michel Hermel

2

1 reference

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5 November 2019

Carine Jacquard

4

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5 November 2019

Carole Escartin

7

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5 November 2019

Philippe Hantraye

8

object named as

Philippe Hantraye

1 reference

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5 November 2019

1

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Nicolas Bizat

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5 November 2019

Frédéric Boyer

3

object named as

Frédéric Boyer

1 reference

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5 November 2019

Christophe Créminon

5

object named as

Christophe Créminon

1 reference

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5 November 2019

author name string

Stéphane Ouary

6

1 reference

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5 November 2019

Stan Kajewski

9

1 reference

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5 November 2019

language of work or name

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publication date

1 June 2003

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5 November 2019

Journal of Neuroscience

1 reference

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5 November 2019

23

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5 November 2019

12

1 reference

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5 November 2019

5020-5030

1 reference

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5 November 2019

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances on the pathogenesis of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase and calpain substrates: roles in synaptic plasticity and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replicating Huntington's disease phenotype in experimental animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain and caspase: can you tell the difference?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energetics in the pathogenesis of neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astroglial trophic support and neuronal cell death: influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A caspase-3-like protease is involved in NF-kappaB activation induced by stimulation of N-methyl-D-aspartate receptors in rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific caspase pathways are activated in the two stages of cerebral infarction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concurrent assessment of calpain and caspase-3 activation after oxygen-glucose deprivation in primary septo-hippocampal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor function in mouse models of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-Jun N-terminal kinase/c-Jun module.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain activation in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain inhibitors: a treatment for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative excitotoxic hypotheses

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3‐Nitropropionic Acid Toxicity in the Striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial defect in Huntington's disease caudate nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calpain cascade. Mu-calpain activates m-calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: killer proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12832525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-12-05020.2003

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12832525%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12832525%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12832525%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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