(Q28505053)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

title

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus (English)

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

1 reference

GOA release 2020-03-11

author

Michael R. Hayden

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

6

Lisa M Ellerby

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

author name string

Juliette Gafni

1

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

Evan Hermel

2

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

Jessica E Young

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

Cheryl L Wellington

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

language of work or name

English

0 references

publication date

23 February 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

24 November 2019

published in

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

volume

279

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

page(s)

20211-20220

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

issue

19

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

24 November 2019

cites work

1 reference

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On chorea. George Huntington, M.D.

21 January 2018

1 reference

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

1 reference

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Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

21 January 2018

1 reference

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Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis

21 January 2018

1 reference

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Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease

21 January 2018

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

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Mutant huntingtin enhances excitotoxic cell death.

21 January 2018

1 reference

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Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

21 January 2018

1 reference

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Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

21 January 2018

1 reference

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Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Cutting to the chase: calpain proteases in cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

The calpain family and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Calpain and caspase: can you tell the difference?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Structure and physiological function of calpains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Nuclear targeting of mutant Huntingtin increases toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Huntingtin contains a highly conserved nuclear export signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

Neurological abnormalities in a knock-in mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401267200

21 January 2018

Identifiers

DOI

10.1074/JBC.M401267200

2 references

Consolidated OpenCitations Corpus – April 2017

3992460

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14981075%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

3992460

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

3992460