(Q61512382)

1

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Danielle J Borg

2

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Brooke E Harcourt

3

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Hui Tong

4

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Yonghua H Sheng

5

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Choa Ping Ng

6

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Indrajit Das

7

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Ran Wang

8

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Alice C-H Chen

9

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Thomas Loudovaris

10

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Thomas W Kay

11

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Helen E Thomas

12

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Jonathan P Whitehead

13

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Johannes B Prins

15

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Michael A McGuckin

https://scigraph.springernature.com/pub.10.1038/nm.3705

16

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language of work or name

English

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publication date

December 2014

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2 November 2014

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published in

Nature Medicine

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volume

20

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issue

12

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page(s)

1417-26

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1417-1426

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exact match

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cites work

Endoplasmic reticulum stress and type 2 diabetes

1 reference

12 December 2020

Lymphotoxin regulates commensal responses to enable diet-induced obesity

1 reference

12 December 2020

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

1 reference

12 December 2020

Diabetes mellitus and the β cell: the last ten years

1 reference

12 December 2020

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

1 reference

12 December 2020

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

1 reference

12 December 2020

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

1 reference

12 December 2020

The endoplasmic reticulum stress response in the pancreatic β-cell

1 reference

12 December 2020

Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes

1 reference

12 December 2020

Regulation of pancreatic β-cell survival by nitric oxide: clinical relevance

1 reference

12 December 2020

Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells.

1 reference

12 December 2020

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

1 reference

12 December 2020

Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets

1 reference

12 December 2020

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

1 reference

12 December 2020

High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22

1 reference

12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

12 December 2020

Interleukin 22 receptor 1 expression in pancreas islets

1 reference

12 December 2020

Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide

1 reference

12 December 2020

Type 2 diabetes as an inflammatory disease

1 reference

12 December 2020

Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2.

1 reference

12 December 2020

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

1 reference

12 December 2020

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

1 reference

12 December 2020

Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals.

1 reference

12 December 2020

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

1 reference

12 December 2020

Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death

1 reference

12 December 2020

Endoplasmic reticulum stress in liver disease

1 reference

12 December 2020

Endoplasmic reticulum stress, obesity and diabetes

1 reference

12 December 2020

Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation

1 reference

12 December 2020

Islet isolation assessment in man and large animals

1 reference

12 December 2020

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

1 reference

12 December 2020

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

1 reference

12 December 2020

Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial.

1 reference

12 December 2020

Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers

1 reference

12 December 2020

Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation.

1 reference

12 December 2020

Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22.

1 reference

12 December 2020

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

1 reference

12 December 2020

Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2

1 reference

12 December 2020

A transgenic mouse model for monitoring endoplasmic reticulum stress

1 reference

12 December 2020

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

1 reference

12 December 2020

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

1 reference

12 December 2020

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

1 reference

12 December 2020

Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin

1 reference

12 December 2020

T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.

1 reference

12 December 2020

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis

1 reference

12 December 2020

Automated islet isolation from human pancreas

1 reference

12 December 2020

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

1 reference

12 December 2020

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

1 reference

12 December 2020

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes

1 reference

12 December 2020

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

1 reference

12 December 2020

The interplay between endoplasmic reticulum stress and inflammation.

1 reference

12 December 2020

IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells.

1 reference

12 December 2020

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

1 reference

12 December 2020

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

1 reference

12 December 2020

Advanced glycation end products are direct modulators of β-cell function

1 reference

12 December 2020

Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis

1 reference

12 December 2020

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

1 reference

12 December 2020

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

1 reference

12 December 2020

Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial

1 reference

12 December 2020

Protective and pathological properties of IL-22 in liver disease: implications for viral hepatitis

1 reference

12 December 2020

Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1β antibody, in patients with type 2 diabetes

1 reference

12 December 2020

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

1 reference

12 December 2020

Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis

1 reference

12 December 2020

X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function

1 reference

12 December 2020

Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells.

1 reference

12 December 2020

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes

1 reference

12 December 2020

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

1 reference

12 December 2020

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

1 reference

12 December 2020