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Endoplasmic reticulum stress and type 2 diabetes
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PubMed
title
Endoplasmic reticulum stress and type 2 diabetes
(English)
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stated in
PubMed
main subject
endoplasmic reticulum
0 references
type 2 diabetes
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author name string
Sung Hoon Back
series ordinal
1
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stated in
Crossref
Randal J. Kaufman
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
2012
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stated in
PubMed
published in
Annual Review of Biochemistry
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PubMed
volume
81
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stated in
PubMed
page(s)
767-93
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PubMed
cites work
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BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
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Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
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AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response
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BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer
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Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element
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Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
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TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
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CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
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Oxidative protein folding in eukaryotes: mechanisms and consequences
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Roles of CHOP/GADD153 in endoplasmic reticulum stress
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Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.
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Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis
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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
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Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
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Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response
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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
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PubMed Central
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21 March 2017
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
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21 March 2017
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
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21 March 2017
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
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21 March 2017
The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins
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21 March 2017
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
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21 March 2017
Signal integration in the endoplasmic reticulum unfolded protein response
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21 March 2017
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.
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21 March 2017
Protein misfolding, functional amyloid, and human disease
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Translational control is required for the unfolded protein response and in vivo glucose homeostasis
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21 March 2017
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell
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PubMed Central
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21 March 2017
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
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21 March 2017
ERAD: the long road to destruction
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21 March 2017
Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
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21 March 2017
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice
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21 March 2017
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
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21 March 2017
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
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21 March 2017
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress
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21 March 2017
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
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21 March 2017
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
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21 March 2017
Regulated translation initiation controls stress-induced gene expression in mammalian cells
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21 March 2017
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
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21 March 2017
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
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21 March 2017
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
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21 March 2017
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
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21 March 2017
Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway
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21 March 2017
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes
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21 March 2017
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
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21 March 2017
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
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21 March 2017
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
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21 March 2017
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
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PubMed Central
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21 March 2017
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
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21 March 2017
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
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21 March 2017
The role of assembly in insulin's biosynthesis
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21 March 2017
An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing
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21 March 2017
Global estimates of the prevalence of diabetes for 2010 and 2030
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7 April 2017
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
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7 April 2017
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
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7 April 2017
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
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7 April 2017
ER stress triggers apoptosis by activating BH3-only protein Bim
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7 April 2017
Mechanisms linking obesity to insulin resistance and type 2 diabetes
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7 April 2017
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
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7 April 2017
Setting the standards: quality control in the secretory pathway
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7 April 2017
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion
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28 September 2017
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation
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28 September 2017
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.
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28 September 2017
PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells
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28 September 2017
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells
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28 September 2017
Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction
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28 September 2017
Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models
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28 September 2017
PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway
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PubMed Central
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28 September 2017
Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate
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28 September 2017
Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes.
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28 September 2017
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.
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28 September 2017
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
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28 September 2017
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.
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PubMed Central
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28 September 2017
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Glucolipotoxicity: fuel excess and beta-cell dysfunction.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Translational control and the unfolded protein response
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
The role of p58IPK in protecting the stressed endoplasmic reticulum
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Oxidative stress and impaired insulin secretion in type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Islet beta cell failure in type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
eIF2 and the control of cell physiology
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Nutrient-secretion coupling in the pancreatic islet beta-cell: recent advances
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Lipid metabolism and vesicle trafficking: more than just greasing the transport machinery
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Calcium, a signaling molecule in the endoplasmic reticulum?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Fatty acids, lipotoxicity and insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
What is the concentration of calcium ions in the endoplasmic reticulum?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
28 September 2017
Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 September 2017
THE RELATION OE DIABETES MELLITUS TO LESIONS OF THE PANCREAS. HYALINE DEGENERATION OF THE ISLANDS OE LANGERHANS.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and non-diabetic individuals
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
retrieved
31 May 2018
The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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31 May 2018
Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684428
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28 November 2018
That which does not kill me makes me stronger: adapting to chronic ER stress
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/22443930
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/22443930
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22443930
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22443930
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species
1 reference
stated in
PubMed
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https://pubmed.ncbi.nlm.nih.gov/22443930
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22443930
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1146/ANNUREV-BIOCHEM-072909-095555
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
349544
OpenCitations bibliographic resource ID
349544
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
349544
PMCID
3684428
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
349544
PubMed ID
22443930
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
349544
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