(Q33420360)

26 July 2017

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. (English)

1 reference

26 July 2017

0 references

endoplasmic reticulum

0 references

3

Mali Ketzinel-Gilad

0 references

author name string

Etti Bachar

1

1 reference

26 July 2017

Yafa Ariav

2

1 reference

26 July 2017

Mali Ketzinel-Gilad

3

1 reference

26 July 2017

Erol Cerasi

4

1 reference

26 July 2017

Nurit Kaiser

5

1 reference

26 July 2017

Gil Leibowitz

6

1 reference

26 July 2017

language of work or name

English

0 references

publication date

23 March 2009

1 reference

26 July 2017

1 reference

26 July 2017

4

1 reference

26 July 2017

3

1 reference

26 July 2017

e4954

1 reference

Creative Commons Attribution 4.0 International

26 July 2017

start time

23 March 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

21 June 2018

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Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

21 June 2018

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Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis

21 June 2018

1 reference

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

21 June 2018

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Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice

21 June 2018

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The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells

21 June 2018

1 reference

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Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells

21 June 2018

1 reference

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Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

21 June 2018

1 reference

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The role for endoplasmic reticulum stress in diabetes mellitus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

21 June 2018

1 reference

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Endoplasmic reticulum stress signaling in pancreatic beta-cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Signal integration in the endoplasmic reticulum unfolded protein response

21 June 2018

1 reference

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 June 2018

1 reference

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Endoplasmic reticulum stress signaling in disease

21 June 2018

1 reference

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Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

21 June 2018

1 reference

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 June 2018

1 reference

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

21 June 2018

1 reference

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 June 2018

1 reference

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TOR signaling in growth and metabolism

21 June 2018

1 reference

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Psammomys obesus, a model for environment-gene interactions in type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Growing roles for the mTOR pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Upstream and downstream of mTOR

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Roles of CHOP/GADD153 in endoplasmic reticulum stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 June 2018

1 reference

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

The consequences of expressing hsp70 in Drosophila cells at normal temperatures

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654723

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

Different role of saturated and unsaturated fatty acids in beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

Regulation of insulin secretion and proinsulin biosynthesis by succinate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004954

The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19305497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A busy cell--endoplasmic reticulum stress in the pancreatic beta-cell

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19305497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Association between PRKCH gene polymorphisms and subcortical silent brain infarction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19305497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0004954

1 reference

26 July 2017

0 references

1 reference

26 July 2017

1 reference