(Q40024663)

16 September 2017

title

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells (English)

1 reference

16 September 2017

0 references

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Michael B Wheeler

3

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author name string

Elida Lai

1

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16 September 2017

George Bikopoulos

2

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16 September 2017

Maria Rozakis-Adcock

4

1 reference

16 September 2017

Allen Volchuk

5

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16 September 2017

publication date

15 January 2008

1 reference

American Journal of Physiology - Endocrinology and Metabolism

16 September 2017

published in

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16 September 2017

volume

294

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16 September 2017

issue

3

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16 September 2017

page(s)

E540-50

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Metabolic engineering with recombinant adenoviruses

16 September 2017

cites work

1 reference

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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

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Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

21 January 2018

1 reference

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Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 January 2018

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Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity

21 January 2018

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The role of stearoyl-CoA desaturase in the control of metabolism

21 January 2018

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Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells

21 January 2018

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Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 January 2018

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Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

21 January 2018

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Pleiotropic effects of fatty acids on pancreatic beta-cells

21 January 2018

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21 January 2018

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Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms

21 January 2018

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 January 2018

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Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

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Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression

21 January 2018

1 reference

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Palmitate-induced apoptosis can occur through a ceramide-independent pathway

21 January 2018

1 reference

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Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.

21 January 2018

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

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Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

21 January 2018

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Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

21 January 2018

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Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

21 January 2018

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Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

21 January 2018

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Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

21 January 2018

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The standardization of pancreatic donors for islet isolations

21 January 2018

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Roles of CHOP/GADD153 in endoplasmic reticulum stress

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

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Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis

21 January 2018

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Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

1 reference

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Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

21 January 2018

1 reference

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Translational control in the endoplasmic reticulum stress response

21 January 2018

1 reference

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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

1 reference

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Role of nitric oxide in obesity-induced beta cell disease

21 January 2018

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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

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Ceramide involvement in apoptosis and apoptotic diseases.

21 January 2018

1 reference

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Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

21 January 2018

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Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

21 January 2018

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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

21 January 2018

1 reference

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

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Signaling the unfolded protein response from the endoplasmic reticulum.

21 January 2018

1 reference

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10.1152/AJPENDO.00478.2007

21 January 2018

Identifiers

DOI

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Fatcat

https://api.fatcat.wiki/v0/release/jyvpricxv5de5dh6uy7sspsetm

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Fatcat ID

release_jyvpricxv5de5dh6uy7sspsetm

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Fatcat

https://api.fatcat.wiki/v0/release/jyvpricxv5de5dh6uy7sspsetm

mapped directly with Wikidata item

30 July 2022

based on heuristic

https://api.fatcat.wiki/v0/release/jyvpricxv5de5dh6uy7sspsetm

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