(Q38903340)

7 September 2017

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity (English)

1 reference

7 September 2017

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Yusuke Sekine

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

David A. Barrett

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Peter M. Fischer

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Heather P Harding

11

1 reference

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5 June 2020

Giovanna R Mallucci

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

M Halliday

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

H Radford

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

J Moreno

4

1 reference

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5 June 2020

N Verity

5

1 reference

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5 June 2020

J le Quesne

6

1 reference

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5 June 2020

C A Ortori

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

C Fromont

9

1 reference

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5 June 2020

publication date

5 March 2015

1 reference

7 September 2017

Cell Death and Disease

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

6

1 reference

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5 June 2020

page(s)

e1672

1 reference

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Creative Commons Attribution 4.0 International

5 June 2020

copyright license

start time

1 March 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4385927/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/cddis.2015.49

0 references

cites work

The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

1 reference

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PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

9 September 2017

1 reference

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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

9 September 2017

1 reference

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An enhanced integrated stress response ameliorates mutant SOD1-induced ALS.

9 September 2017

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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

9 September 2017

1 reference

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The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease

9 September 2017

1 reference

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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

9 September 2017

1 reference

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Targeting the unfolded protein response in neurodegeneration: A new approach to therapy

9 September 2017

1 reference

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Pharmacological brake-release of mRNA translation enhances cognitive memory

9 September 2017

1 reference

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Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

9 September 2017

1 reference

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Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

9 September 2017

1 reference

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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

9 September 2017

1 reference

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

9 September 2017

1 reference

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The unfolded protein response in familial amyotrophic lateral sclerosis

9 September 2017

1 reference

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The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4385927

Translational control of long-lasting synaptic plasticity and memory

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4385927

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

9 September 2017

1 reference

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Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

9 September 2017

1 reference

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The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4385927

Signal integration in the endoplasmic reticulum unfolded protein response

9 September 2017

1 reference

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

9 September 2017

1 reference

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The roles of intracellular protein-degradation pathways in neurodegeneration

9 September 2017

1 reference

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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

9 September 2017

1 reference

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Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease

9 September 2017

1 reference

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

9 September 2017

1 reference

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Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

9 September 2017

1 reference

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Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

9 September 2017

1 reference

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Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

14 September 2017

1 reference

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TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

14 September 2017

1 reference

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A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

22 August 2018

1 reference

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SUnSET, a nonradioactive method to monitor protein synthesis.

22 August 2018

1 reference

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Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.

22 August 2018

1 reference

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Activation of the unfolded protein response in Parkinson's disease.

22 August 2018

1 reference

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22 August 2018

Identifiers

DOI

10.1038/CDDIS.2015.49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25741597%20AND%20SRC:MED&resulttype=core&format=json