(Q28269333)

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Point mutations of the mtDNA control region in normal and neurodegenerative human brains

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Low mutational burden of individual acquired mitochondrial DNA mutations in brain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial DNA and ageing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial metabolism of reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Extension of murine life span by overexpression of catalase targeted to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Gene regulation and DNA damage in the ageing human brain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Selective increase in cellular A beta 42 is related to apoptosis but not necrosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Cybrids in Alzheimer's disease: a cellular model of the disease?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Cytochrome oxidase deficiency in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mechanism of toxicity in rotenone models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Sequence analysis of the entire mitochondrial genome in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Parkin enhances mitochondrial biogenesis in proliferating cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

DJ-1, a novel regulator of the tumor suppressor PTEN.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Amyotrophic lateral sclerosis: a proposed mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial defect in Huntington's disease caudate nucleus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Transcriptional abnormalities in Huntington disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021

Progressive loss of striatal neurons causes motor dysfunction in MND2 mutant mice and is not prevented by Bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05292

7 January 2021