(Q43906174)

27 November 2017

title

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome (English)

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27 November 2017

Jorge Busciglio

1

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27 November 2017

Alejandra Pelsman

2

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27 November 2017

Caine Wong

3

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27 November 2017

Gustavo Pigino

4

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27 November 2017

Menglan Yuan

5

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27 November 2017

Hiroshi Mori

6

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27 November 2017

Bruce A Yankner

7

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27 November 2017

language of work or name

English

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publication date

1 February 2002

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27 November 2017

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27 November 2017

volume

33

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27 November 2017

issue

5

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27 November 2017

page(s)

677-688

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Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

27 November 2017

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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

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beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins

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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

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7 January 2021

Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.

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Activation of a neurofilament kinase, a tau kinase, and a tau phosphatase by decreased ATP levels in nerve growth factor-differentiated PC-12 cells

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A one-hit model of cell death in inherited neuronal degenerations

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7 January 2021

The neurobiologic consequences of Down syndrome

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7 January 2021

Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome

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7 January 2021

Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

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7 January 2021

Transport of vesicular stomatitis virus glycoprotein in a cell-free extract

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7 January 2021

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

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7 January 2021

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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7 January 2021

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

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7 January 2021

Intraneuronal Abeta42 accumulation in human brain.

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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7 January 2021

The mitochondrial electron transport and oxidative phosphorylation system

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7 January 2021

Mitochondrial abnormalities in Alzheimer's disease.

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7 January 2021

Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome.

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7 January 2021

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

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7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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7 January 2021

Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease.

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7 January 2021

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

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7 January 2021

Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases

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7 January 2021

The pathological association between Down syndrome and Alzheimer disease

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7 January 2021

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

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7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

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7 January 2021

Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein

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7 January 2021

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

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7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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7 January 2021

Mitochondria in neurodegeneration: bioenergetic function in cell life and death

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7 January 2021

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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7 January 2021

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

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7 January 2021

Early glycoxidation damage in brains from Down's syndrome.

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7 January 2021

Selective increase in cellular A beta 42 is related to apoptosis but not necrosis.

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7 January 2021

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

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7 January 2021

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

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7 January 2021

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

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7 January 2021

Molecular mapping of Alzheimer-type dementia in Down's syndrome.

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7 January 2021

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

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7 January 2021

Mitochondrial membrane potential monitored by JC-1 dye.

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7 January 2021

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

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7 January 2021

Diminished glutathione levels cause spontaneous and mitochondria-mediated cell death in neurons from trisomy 16 mice: a model of Down's syndrome

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7 January 2021

Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome.

1 reference

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7 January 2021

Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome.

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7 January 2021

Alzheimer's disease: genes, proteins, and therapy

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7 January 2021

Apoptosis induced by HIV-1 infection of the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

The survival of rat cerebral cortical neurons in the presence of trophic APP peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900604-9

7 January 2021

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

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7 January 2021

10.1016/S0896-6273(02)00604-9

Identifiers

DOI

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27 November 2017

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