(Q42461079)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

title

Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

S Schuchmann

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

W Müller

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

U Heinemann

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

language of work or name

English

0 references

publication date

1 September 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

page(s)

7216-7231

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

issue

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicity

4 December 2019

cites work

1 reference

12 December 2020

Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo.

1 reference

12 December 2020

Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status

1 reference

12 December 2020

Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: implications for neurodegeneration

1 reference

12 December 2020

Rat hippocampal neurons in dispersed cell culture.

1 reference

12 December 2020

On the probabilistic nature of excitotoxic neuronal death in hippocampal neurons

1 reference

12 December 2020

Cultured hippocampal neurons from trisomy 16 mouse, a model for Down's syndrome, have an abnormal action potential due to a reduced inward sodium current.

1 reference

12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

12 December 2020

Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species.

1 reference

12 December 2020

Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase

1 reference

12 December 2020

Crosstalk between nuclear and mitochondrial genomes

1 reference

12 December 2020

Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology

1 reference

12 December 2020

Localization of mitochondria in living cells with rhodamine 123

1 reference

12 December 2020

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition.

1 reference

12 December 2020

The neuropathology of Alzheimer's disease investigated by transplantation of mouse Trisomy 16 hippocampal tissues

1 reference

12 December 2020

Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse

1 reference

12 December 2020

Voltage-activated sodium conductances in cultured normal and trisomy 16 dorsal root ganglion neurons from the fetal mouse.

1 reference

12 December 2020

Isolated hippocampal neurons in cryopreserved long-term cultures: development of neuroarchitecture and sensitivity to NMDA.

1 reference

12 December 2020

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1 reference

12 December 2020

Cell damage by excess CuZnSOD and Down's syndrome

1 reference

12 December 2020

Mitochondrial dysfunction is a primary event in glutamate neurotoxicity

1 reference

12 December 2020

Relation between mitochondrial calcium transport and control of energy metabolism

1 reference

12 December 2020

Oxidants in mitochondria: from physiology to diseases

1 reference

12 December 2020

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

12 December 2020

Enzyme function of copper, zinc superoxide dismutase as a free radical generator

1 reference

12 December 2020

Abnormal calcium homeostasis in astrocytes from the trisomy 16 mouse.

1 reference

12 December 2020

Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body

1 reference

12 December 2020

Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome

1 reference

12 December 2020

Metabolism of Oxygen Derivatives in Down's Syndrome

1 reference

12 December 2020

Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases.

1 reference

12 December 2020

Characterization of 2',7'-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide.

1 reference

12 December 2020

Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokines

1 reference

12 December 2020

Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.

1 reference

12 December 2020

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

12 December 2020

Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture

1 reference

12 December 2020

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells

1 reference

12 December 2020

Mitochondrial transmembrane ion distribution during anoxia

1 reference

12 December 2020

Excitotoxic cell death

1 reference

12 December 2020

Mechanisms by which mitochondria transport calcium

1 reference

12 December 2020

Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1 reference

12 December 2020

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1 reference

12 December 2020

Development and selective neurodegeneration in cell cultures from different hippocampal regions

1 reference

12 December 2020

Mitochondria and Na+/Ca2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons

1 reference

12 December 2020

Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.

1 reference

12 December 2020

The relation of oxidative stress and hyperexcitation to neurological disease

1 reference

12 December 2020

A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor

1 reference

12 December 2020

A new generation of Ca2+ indicators with greatly improved fluorescence properties

1 reference

12 December 2020

Systematic approach to the study of trisomy in the mouse. II

1 reference

12 December 2020

Autofluorescence of viable cultured mammalian cells

1 reference

12 December 2020

Mitochondrial calcium transport: physiological and pathological relevance

1 reference

12 December 2020

Fatty acid-induced Ca(2+)-dependent uncoupling and activation of external pathway of NADH oxidation are coupled to cyclosporin A-sensitive mitochondrial permeability transition

1 reference

12 December 2020

Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1 reference

12 December 2020

On the role of ADP to increase the inhibitory effect of cyclosporin on mitochondrial membrane permeability transition.

1 reference

12 December 2020

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

1 reference

12 December 2020

Intracellular calcium homeostasis

1 reference

12 December 2020

Cyclosporin A rescues thymocytes from apoptosis induced by very low concentrations of thapsigargin: effects on mitochondrial function

1 reference

12 December 2020

Enhanced production of superoxide anion by microglia from trisomy 16 mice

1 reference

12 December 2020

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

1 reference

12 December 2020

Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

1 reference

12 December 2020

Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress

1 reference

12 December 2020

Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

1 reference

12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

12 December 2020

Calcium homeostasis in rat septal neurons in tissue culture

1 reference

12 December 2020

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization

1 reference

12 December 2020

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1 reference

12 December 2020

Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise

1 reference

12 December 2020

Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

1 reference

12 December 2020

Down syndrome, Alzheimer's disease and the trisomy 16 mouse

1 reference

12 December 2020

Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

1 reference

12 December 2020

Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.

1 reference

12 December 2020

Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

1 reference

12 December 2020

Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration

1 reference

12 December 2020

Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose.

1 reference

12 December 2020

A fine structural study of the hippocampus and dorsal root ganglion in mouse trisomy 16, a model of Down's syndrome.

1 reference

12 December 2020

Further characterization of the events involved in mitochondrial Ca2+ release and pore formation by prooxidants

1 reference

12 December 2020

Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons

1 reference

12 December 2020

Calcium: still center-stage in hypoxic-ischemic neuronal death

1 reference

12 December 2020

Calcineurin and mitochondrial function in glutamate-induced neuronal cell death.

1 reference

12 December 2020

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.

1 reference

12 December 2020

Glutathione levels and nerve cell loss in hippocampal cultures from trisomy 16 mouse--a model of Down syndrome.

1 reference

12 December 2020

Down's syndrome: morphological remodelling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice

1 reference

12 December 2020

Oxidative damage to mitochondria is mediated by the Ca(2+)-dependent inner-membrane permeability transition

1 reference

12 December 2020

Glutamate neurotoxicity and diseases of the nervous system

1 reference

12 December 2020

Electrophysiological analysis of cultured fetal mouse dorsal root ganglion neurons transgenic for human superoxide dismutase-1, a gene in the Down syndrome region of chromosome 21

1 reference

12 December 2020

Down's syndrome: Abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase

1 reference

12 December 2020

Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition

1 reference

12 December 2020

Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties

1 reference

12 December 2020

Morphology of dissociated hippocampal cultures from fetal mice

1 reference

12 December 2020

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

1 reference

12 December 2020

Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition

1 reference

12 December 2020

Impaired Ca-signaling in astrocytes from the Ts16 mouse model of Down syndrome.

1 reference

12 December 2020

10.1523/JNEUROSCI.18-18-07216.1998

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9736644%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference