(Q49078080)

English

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

scientific article published in February 2001

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 February 2018

http://europepmc.org/abstract/MED/11157069

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

0 references

phosphorylation

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

G Pigino

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

A Pelsman

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

H Mori

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

J Busciglio

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

language of work or name

0 references

publication date

1 February 2001

1 reference

Europe PubMed Central

PubMed publication ID

18 February 2018

http://europepmc.org/abstract/MED/11157069

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

21

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

834-842

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution and possible interactions of actin-associated proteins and cell adhesion molecules of nerve growth cones

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface expression of the Alzheimer disease-related presenilin proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 cleavage is a universal event in human organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of presenilin I-467, I-463 and I-374.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear access and action of notch in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch1 inhibits neurite outgrowth in postmitotic primary neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear Notch1 signaling and the regulation of dendritic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeletal reorganization of human platelets after stimulation revealed by the quick-freeze deep-etch technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of presenilins with the filamin family of actin-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ins and outs of notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient increases in intracellular calcium result in prolonged site-selective increases in Tau phosphorylation through a glycogen synthase kinase 3beta-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein topology of presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin is required for proper morphology and function of neurons in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methodological variables in the assessment of beta amyloid neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling downstream of activated mammalian Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-03-00834.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

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