(Q49078080)

English

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

scientific article published in February 2001

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 February 2018

http://europepmc.org/abstract/MED/11157069

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

0 references

phosphorylation

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

G Pigino

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

A Pelsman

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

H Mori

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

J Busciglio

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

language of work or name

0 references

publication date

1 February 2001

1 reference

Europe PubMed Central

PubMed publication ID

18 February 2018

http://europepmc.org/abstract/MED/11157069

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

21

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

834-842

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution and possible interactions of actin-associated proteins and cell adhesion molecules of nerve growth cones

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface expression of the Alzheimer disease-related presenilin proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 cleavage is a universal event in human organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of presenilin I-467, I-463 and I-374.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear access and action of notch in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch1 inhibits neurite outgrowth in postmitotic primary neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear Notch1 signaling and the regulation of dendritic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeletal reorganization of human platelets after stimulation revealed by the quick-freeze deep-etch technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of presenilins with the filamin family of actin-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ins and outs of notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient increases in intracellular calcium result in prolonged site-selective increases in Tau phosphorylation through a glycogen synthase kinase 3beta-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein topology of presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin is required for proper morphology and function of neurons in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methodological variables in the assessment of beta amyloid neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling downstream of activated mammalian Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/11157069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-03-00834.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762317&resulttype=core&format=json

12 May 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q49078080&oldid=1391232977"