Wikidata

(Q21116651)

English

Pyruvate kinase M1/2

mammalian protein found in Homo sapiens

  • thyroid hormone-binding protein 1
  • PK, muscle type
  • pyruvate kinase isozymes M1/M2
  • CTHBP
  • PKM
  • epididymis secretory protein Li 30
  • pyruvate kinase muscle isozyme
  • OIP-3
  • pyruvate kinase 2/3
  • pyruvate kinase, muscle
  • cytosolic thyroid hormone-binding protein
  • pyruvate kinase PKM
  • p58
  • thyroid hormone-binding protein, cytosolic
  • OPA-interacting protein 3
  • tumor M2-PK
  • THBP1
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
12 references
retrieved
8 April 2019
stated in
JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells.
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Functional specialization of beta-arrestin interactions revealed by proteomic analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
retrieved
8 April 2019
stated in
Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IPI
pyruvate kinase activity
determination method
IEA
EXP
IDA
TAS
9 references
retrieved
31 October 2017
stated in
Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
31 October 2017
stated in
Isolation and characterization of the human pyruvate kinase M gene
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
31 October 2017
stated in
Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
31 October 2017
stated in
Identification of small molecule inhibitors of pyruvate kinase M2
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
EXP
retrieved
31 October 2017
stated in
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
EXP
pyruvate kinase activity
determination method
EXP
IBA
IDA
IEA
TAS
10 references
retrieved
1 January 2018
stated in
Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
1 January 2018
stated in
Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
1 January 2018
stated in
Isolation and characterization of the human pyruvate kinase M gene
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
1 January 2018
stated in
Identification of small molecule inhibitors of pyruvate kinase M2
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IBA
retrieved
1 January 2018
stated in
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
EXP
retrieved
1 January 2018
stated in
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
EXP
pyruvate kinase activity
determination method
IBA
IDA
IEA
TAS
8 references
retrieved
8 April 2019
stated in
Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
8 April 2019
stated in
Isolation and characterization of the human pyruvate kinase M gene
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
8 April 2019
stated in
Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IEA
retrieved
8 April 2019
stated in
Identification of small molecule inhibitors of pyruvate kinase M2
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
IBA
cell component
extracellular exosome
determination method
IDA
8 references
retrieved
31 October 2017
stated in
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
Intestinal epithelial cells secrete exosome-like vesicles
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
Protein profile of exosomes from trabecular meshwork cells
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
retrieved
31 October 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618
determination method
IDA
extracellular exosome
determination method
HDA
7 references
retrieved
8 April 2019
stated in
Protein profile of exosomes from trabecular meshwork cells
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
HDA
retrieved
8 April 2019
stated in
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
HDA
retrieved
8 April 2019
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
HDA
retrieved
8 April 2019
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
HDA
retrieved
8 April 2019
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
HDA
retrieved
8 April 2019
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
HDA
retrieved
8 April 2019
stated in
Intestinal epithelial cells secrete exosome-like vesicles
GOA
curator
UniProt
UniProt protein ID
P14618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618
determination method
HDA
biological process

Identifiers

MeSH descriptor ID
D000097810
subject named as
Thyroid Hormone-Binding Proteins
0 references
MeSH tree code
D12.776.157.774
0 references
D12.776.543.935
0 references
PDB structure ID
 
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