Wikidata

(Q21116814)

English

DNA damage inducible transcript 3

mammalian protein found in Homo sapiens

  • growth arrest and DNA damage-inducible protein GADD153
  • DNA damage-inducible transcript 3 protein
  • CHOP-10
  • CHOP
  • alternative DDIT3 protein
  • c/EBP-homologous protein 10
  • CCAAT/enhancer-binding protein homologous protein
  • DDIT3
  • DDIT-3
  • C/EBP zeta
  • C/EBP-homologous protein
In more languages

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IEA
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
retrieved
8 April 2019
stated in
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
retrieved
8 April 2019
stated in
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
retrieved
8 April 2019
stated in
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
biological process
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
determination method
IDA
ISS
IGI
IEA
IMP
6 references
retrieved
8 April 2019
stated in
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
ISS
retrieved
8 April 2019
stated in
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IMP
retrieved
8 April 2019
stated in
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IEA
retrieved
8 April 2019
stated in
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
retrieved
8 April 2019
stated in
Q24299363
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
determination method
IDA
TAS
IMP
IEA
6 references
retrieved
27 March 2018
stated in
Roles of CHOP/GADD153 in endoplasmic reticulum stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638
determination method
TAS
retrieved
27 March 2018
stated in
The endoplasmic reticulum stress response in aging and age-related diseases
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638
determination method
TAS
retrieved
27 March 2018
stated in
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638
determination method
IMP
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638
determination method
IEA
retrieved
27 March 2018
stated in
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638
determination method
IDA
retrieved
27 March 2018
stated in
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638
determination method
IDA
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
determination method
IBA
IDA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
The endoplasmic reticulum stress response in aging and age-related diseases
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
TAS
retrieved
8 April 2019
stated in
Roles of CHOP/GADD153 in endoplasmic reticulum stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
TAS
retrieved
8 April 2019
stated in
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IEA
retrieved
8 April 2019
stated in
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
retrieved
8 April 2019
stated in
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
GOA
curator
UniProt
UniProt protein ID
P35638
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638
determination method
IBA

Identifiers

MeSH descriptor ID
D051742
subject named as
Transcription Factor CHOP
0 references
 
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