Wikidata

(Q21116835)

English

VRK serine/threonine kinase 1

mammalian protein found in Homo sapiens

  • serine/threonine-protein kinase VRK1
  • vaccinia related kinase 1
  • Vaccinia-related kinase 1
  • vaccinia virus B1R-related kinase 1
  • VRK1
In more languages

Statements

molecular function
protein binding
determination method
IPI
14 references
retrieved
8 April 2019
stated in
Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase
GOA
curator
UniProt
UniProt protein ID
Q99986
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
retrieved
8 April 2019
stated in
Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99986
determination method
IPI
cell component
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21116835&oldid=2022967812"