(Q24338044)

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Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications

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12 February 2020

Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications (English)

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12 February 2020

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phosphorylation

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Marta Vázquez-Cedeira

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12 February 2020

Ephrat Levy-Lahad

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12 February 2020

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12 February 2020

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Marta Sanz-García

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12 February 2020

Efrat Kellerman

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12 February 2020

Paul Renbaum

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3 September 2011

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12 February 2020

Journal of Proteomics

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12 February 2020

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12 February 2020

548-560

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12 February 2020

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12 February 2020

Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Coilin phosphorylation mediates interaction with SMN and SmB'.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and the Cajal body: modification in search of function

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of VRK1 as a new player in the control of biological processes required for cell division.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Statistical analysis of protein kinase specificity determinants.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of an oriented peptide library to determine the optimal substrates of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of the gene causing type 1 spinocerebellar ataxia.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting cancer with small molecule kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis and prediction of substrate specificity in protein serine/threonine kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Self-association of coilin reveals a common theme in nuclear body localization

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathological consequences of VCP mutations on human striated muscle.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Phospho.ELM: a database of phosphorylation sites--update 2008.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The genetics of spinal muscular atrophies

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The Cajal body and histone locus body

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear ataxias.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase complement of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Scaffold proteins: hubs for controlling the flow of cellular information

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

CAJAL BODIES: A Long History of Discovery

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Phospho.ELM: a database of experimentally verified phosphorylation sites in eukaryotic proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of Cajal body number is mediated by the coilin C-terminus

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Human VRK1 is an early response gene and its loss causes a block in cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JPROT.2011.08.019

7 January 2021

based on heuristic

inferred from DOI database lookup

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