(Q24337220)

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The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

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The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines (English)

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VRK serine/threonine kinase 2

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GOA release 2020-03-11

protein autophosphorylation

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GOA release 2020-03-11

object named as

Sandra Blanco

1

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Francisco M Vega

object named as

Francisco M Vega

3

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object named as

Pedro A Lazo

4

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author name string

Lucia Klimcakova

2

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language of work or name

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publication date

June 2006

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273

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2487-504

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11

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Mapping of the p53 and mdm-2 interaction domains

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

21 January 2018

Regulation of p53 function and stability by phosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

21 January 2018

Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of p53 function

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Vaccinia virus gene B1R encodes a 34-kDa serine/threonine protein kinase that localizes in cytoplasmic factories and is packaged into virions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanism of the interaction between MDM2 and p53.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Multisite phosphorylation and the integration of stress signals at p53.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative proteomic analysis of chromatin-associated factors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Post-translational modification of p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Live or let die: the cell's response to p53

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cisplatinum and taxol induce different patterns of p53 phosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

The loss of mdm2 induces p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Limited role of N-terminal phosphoserine residues in the activation of transcription by p53.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

p300/CBP/p53 interaction and regulation of the p53 response

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Stereotyped and specific gene expression programs in human innate immune responses to bacteria

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Role for p300 in stabilization of p53 in the response to DNA damage

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Acetylation of p53 inhibits its ubiquitination by Mdm2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA-dependent acetylation of p53 by the transcription coactivator p300.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of target genes of the p16INK4A-pRB-E2F pathway.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinases and phosphatases in the Drosophila genome

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

p53-Mdm2--the affair that never ends

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Late onset of spermatogenesis and gain of fertility in POG-deficient mice indicate that POG is not necessary for the proliferation of spermatogonia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase complement of the human genome

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

HRR25, a putative protein kinase from budding yeast: association with repair of damaged DNA.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

The vaccinia virus B1R gene product is a serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Vaccinia virus B1 kinase: phenotypic analysis of temperature-sensitive mutants and enzymatic characterization of recombinant proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Stress signals utilize multiple pathways to stabilize p53

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of serine 18 regulates distinct p53 functions in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacogenomic analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Global gene expression analysis of the developing postnatal mouse retina

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05256.X

7 January 2021

based on heuristic

inferred from DOI database lookup

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