(Q33184867)

23 July 2017

Molecular mechanism of the interaction between MDM2 and p53. (English)

1 reference

23 July 2017

5

Alan R Fersht

1 reference

23 July 2017

Oliver Schon

1

1 reference

23 July 2017

Assaf Friedler

series ordinal

2

1 reference

23 July 2017

Mark Bycroft

series ordinal

3

1 reference

23 July 2017

Stefan M V Freund

series ordinal

4

1 reference

23 July 2017

language of work or name

English

0 references

publication date

1 October 2002

1 reference

Journal of Molecular Biology

23 July 2017

1 reference

23 July 2017

323

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23 July 2017

491-501

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23 July 2017

3

1 reference

Multiple roles of the tumor suppressor p53.

23 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Regulation of p53 function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Solution conformation of an essential region of the p53 transactivation domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Phosphorylation of p53 serine 15 increases interaction with CBP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

A simple method for displaying the hydropathic character of a protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

P63 and P73: P53 mimics, menaces and more

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Rapid, electrostatically assisted association of proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Sequence-specific 1H, 15N, and 13C assignment of the N-terminal domain of the human oncoprotein MDM2 that binds to p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Experimental assignment of the structure of the transition state for the association of barnase and barstar

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900852-5

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0022-2836(02)00852-5

1 reference

23 July 2017

1 reference