(Q21117805)

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

phosphoric diester hydrolase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

1 reference

5 June 2018

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

1 reference

5 June 2018

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

3',5'-cyclic-nucleotide phosphodiesterase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

3',5'-cyclic-AMP phosphodiesterase activity

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

5 June 2018

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

5 June 2018

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

5 June 2018

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

3',5'-cyclic-AMP phosphodiesterase activity

IDA

5 references

8 April 2019

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

3 references

8 April 2019

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

perinuclear region of cytoplasm

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

sensory perception of smell

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

regulation of cAMP-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

cAMP catabolic process

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

31 October 2017

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

31 October 2017

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815

regulation of protein kinase A signaling

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815

TAS

cAMP catabolic process

1 reference

8 April 2019

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7399

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

5260

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

5292

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1752

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL484785

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL19449

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL332750

flavoxate hydrochloride

object has role

reaction inhibitor

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200875

has part(s)

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

HD/PDEase domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016