(Q28115926)

English

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

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scholarly article

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4 January 2017

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram (English)

1 reference

4 January 2017

Phosphodiesterase 4A

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GOA release 2020-03-11

signal transduction

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GOA release 2020-03-11

author name string

E. Huston

1

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4 January 2017

L. Pooley

2

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4 January 2017

P. Julien

3

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4 January 2017

G. Scotland

4

1 reference

4 January 2017

I. McPhee

5

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4 January 2017

M. Sullivan

6

1 reference

4 January 2017

G. Bolger

7

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4 January 2017

M. D. Houslay

8

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4 January 2017

language of work or name

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publication date

6 December 1996

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4 January 2017

Journal of Biological Chemistry

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4 January 2017

271

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4 January 2017

31334–31344

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4 January 2017

49

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4 January 2017

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Diversity in cyclic nucleotide phosphodiesterase isoenzyme families

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Regulation of intracellular cyclic AMP concentrations in hepatocytes involves the integrated activation and desensitization of adenylyl cyclase coupled with the action and activation of specific isoforms of cyclic AMP phosphodiesterase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Purification and characterization of high-affinity cyclic adenosine monophosphate phosphodiesterase from dog kidney

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Purification and properties of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

The determination of enzyme inhibitor constants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

A kinetic evaluation of monoamine oxidase activity in rat liver mitochondrial outer membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Stereospecific binding of the antidepressant rolipram to brain protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Mutational analysis of phosphodiesterase in Drosophila.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Microtubules in the Cytoplasm of an Amoeba

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.49.31334

21 January 2018

Identifiers

10.1074/JBC.271.49.31334

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1 reference

4 January 2017

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