(Q21119697)

English

Phosphodiesterase 12

mammalian protein found in Homo sapiens

mitochondrial deadenylase
3.1.13.4
PDE12
2',5'-phosphodiesterase 12
2'-phosphodiesterase

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Statements

1 reference

13 November 2019

Endonuclease/exonuclease/phosphatase superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q6L8Q7

Endonuclease/exonuclease/phosphatase family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

poly(A)-specific ribonuclease activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IEA

3'-5'-exoribonuclease activity

3 references

9 May 2019

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

9 May 2019

Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IDA

oligoribonucleotidase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

TAS

3'-5'-exoribonuclease activity

3 references

9 May 2019

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

9 May 2019

Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

3 references

9 May 2019

Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

9 May 2019

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IEA

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

1 reference

8 April 2019

Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IMP

mitochondrial mRNA catabolic process

determination method

IMP

cellular response to interferon-alpha

1 reference

9 May 2019

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IMP

regulation of mitochondrial mRNA stability

1 reference

9 May 2019

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IMP

positive regulation of viral genome replication

1 reference

9 May 2019

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IMP

negative regulation of cell death

1 reference

9 May 2019

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IDA

cellular response to interferon-gamma

1 reference

9 May 2019

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IDA

cellular response to dsRNA

1 reference

9 May 2019

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IDA

nucleic acid phosphodiester bond hydrolysis

1 reference

9 May 2019

Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IDA

negative regulation of oxidative phosphorylation

1 reference

9 May 2019

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

IMP

RNA phosphodiester bond hydrolysis, exonucleolytic

determination method

IMP

defense response to virus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6L8Q7

determination method

TAS

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

3.1.13.4

1 reference

6 January 2016

http://www.uniprot.org/uniprot/Q6L8Q7.txt?version=92

has part(s)

Endonuclease/exonuclease/phosphatase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q6L8Q7

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

English

(Q21119697)

Phosphodiesterase 12

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