(Q21120885)

http://www.ebi.ac.uk/interpro/protein/Q8N6T7

DHS-like NAD/FAD-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N6T7

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

NAD-dependent histone deacetylase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

transcription corepressor activity

ISS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

protein deacetylase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

3 references

9 May 2019

Human SIRT6 promotes DNA end resection through CtIP deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

NAD+ ADP-ribosyltransferase activity

IPI

1 reference

9 May 2019

Sirtuin functions in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

NAD-dependent protein deacetylase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

histone deacetylase activity

TAS

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

NAD-dependent histone deacetylase activity (H3-K9 specific)

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

8 April 2019

Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

negative regulation of glycolytic process

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

regulation of double-strand break repair via homologous recombination

1 reference

9 May 2019

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

positive regulation of fibroblast proliferation

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

protein deacetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

negative regulation of glucose import

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

response to nutrient levels

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

protein destabilization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

post-embryonic cardiac muscle cell growth involved in heart morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

negative regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

positive regulation of stem cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

negative regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

histone deacetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

histone H3-K9 modification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

histone H3-K9 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

positive regulation of chondrocyte proliferation

protein ADP-ribosylation

1 reference

9 May 2019

Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

positive regulation of blood vessel branching

IMP

1 reference

9 May 2019

SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

positive regulation of vascular endothelial cell proliferation

IMP

1 reference

9 May 2019

SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

negative regulation of transcription by RNA polymerase II

IMP

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

histone H3 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7

Sirtuin family, catalytic core domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N6T7

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016