(Q24305332)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

GOA release 2020-03-11

author

Carlos Sebastian

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Melissa Gymrek

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Joanne Edwards

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Ralph Weissleder

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Paul G Shiels

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

David B. Lombard

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

21

Aviv Regev

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

5

Alon Goren

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

20

Bradley E Bernstein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author name string

Bernadette M M Zwaans

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Dafne M Silberman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Lei Zhong

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Oren Ram

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jessica Truelove

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Alexander R Guimaraes

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Debra Toiber

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Claudia Cosentino

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Joel K Greenson

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Alasdair I MacDonald

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Liane McGlynn

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Fraser Maxwell

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Sofia Giacosa

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Ernesto Guccione

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Raul Mostoslavsky

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

language of work or name

English

0 references

publication date

1 December 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

151

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

page(s)

1185-1199

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

19 February 2020

cites work

1 reference

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Human SIRT6 promotes DNA end resection through CtIP deacetylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Understanding the Warburg effect: the metabolic requirements of cell proliferation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

19 March 2017

The Hallmarks of Cancer

1 reference

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Hallmarks of Cancer: The Next Generation

19 March 2017

1 reference

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

On the Origin of Cancer Cells

19 March 2017

2 references

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19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

The sirtuin SIRT6 regulates lifespan in male mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

The landscape of somatic copy-number alteration across human cancers

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

MYC on the path to cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Charting histone modifications and the functional organization of mammalian genomes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

THE METABOLISM OF TUMORS IN THE BODY

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Recent progress in the biology and physiology of sirtuins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

SIRT6 promotes DNA repair under stress by activating PARP1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

MYC as a regulator of ribosome biogenesis and protein synthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Close association of RNA polymerase II and many transcription factors with Pol III genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Microarray meta-analysis defines global angiogenesis-related gene expression signatures in human carcinomas.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Over-expression of facilitative glucose transporter genes in human cancer.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526953

Sirtuin 1 in malignant transformation: friend or foe?

29 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

c-Myc regulates transcriptional pause release

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

TopHat: discovering splice junctions with RNA-Seq

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

BEDTools: a flexible suite of utilities for comparing genomic features

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

The UCSC Genome Browser database: update 2011

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

PANTHER: a library of protein families and subfamilies indexed by function

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Imaging of mediastinal lymph nodes: CT, MR, and FDG PET

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Sirtuins, metabolism, and cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.10.047

7 January 2021

10.1016/J.CELL.2012.10.047

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

23217706

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23217706%20AND%20SRC:MED&resulttype=core&format=json