(Q21988569)

http://www.ebi.ac.uk/interpro/protein/P59941

DHS-like NAD/FAD-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P59941

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

NAD-dependent histone deacetylase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

transcription corepressor activity

ISS

1 reference

9 May 2019

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

1 reference

9 May 2019

Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

NAD+-protein-arginine ADP-ribosyltransferase activity

1 reference

9 May 2019

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

NAD-dependent histone deacetylase activity (H3-K9 specific)

IDA

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59941&geneProductId=UniProtKB:P59941

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59941&geneProductId=UniProtKB:P59941

24 April 2018

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59941&geneProductId=UniProtKB:P59941

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59941&geneProductId=UniProtKB:P59941

NAD-dependent histone deacetylase activity (H3-K9 specific)

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

histone deacetylase activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

NAD-dependent histone deacetylase activity (H3-K9 specific)

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

14 February 2019

Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

biological process

protein ADP-ribosylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

1 reference

9 May 2019

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

regulation of double-strand break repair via homologous recombination

positive regulation of fibroblast proliferation

1 reference

9 May 2019

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

negative regulation of glucose import

1 reference

9 May 2019

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

response to nutrient levels

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

protein destabilization

1 reference

9 May 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

negative regulation of transcription, DNA-templated

1 reference

9 May 2019

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

positive regulation of stem cell proliferation

1 reference

9 May 2019

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

1 reference

9 May 2019

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

negative regulation of cell population proliferation

1 reference

9 May 2019

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

histone H3-K9 modification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

protein deacetylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

histone H3-K9 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

histone deacetylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

histone H3 deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59941

Sirtuin family, catalytic core domain

has part(s)

1 reference

stated in

InterPro Release 71.0