Wikidata

(Q21130471)

English

DNA topoisomerase I

mammalian protein found in Homo sapiens

  • type I DNA topoisomerase
  • Scl-70 antigen
  • topoisomerase (DNA) I
  • DNA topoisomerase 1
  • TOP1
  • TOP1 protein, human
In more languages

Statements

part of
molecular function
DNA topoisomerase type I (single strand cut, ATP-independent) activity
determination method
IDA
IEA
IMP
10 references
retrieved
26 September 2017
stated in
Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
Biochemical and biophysical analyses of recombinant forms of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
Identification of a nucleolin binding site in human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
The domain organization of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
26 September 2017
stated in
The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IDA
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IPI
retrieved
8 April 2019
stated in
NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a nucleolin binding site in human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IPI
DNA topoisomerase type I (single strand cut, ATP-independent) activity
determination method
IBA
IDA
IEA
IMP
10 references
retrieved
8 April 2019
stated in
Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Identification of a nucleolin binding site in human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Biochemical and biophysical analyses of recombinant forms of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
The domain organization of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
8 April 2019
stated in
The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IBA
cell component
nucleus
determination method
IDA
IEA
6 references
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
26 September 2017
stated in
Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IDA
retrieved
26 September 2017
stated in
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IDA
retrieved
26 September 2017
stated in
A novel nuclear localization signal in human DNA topoisomerase I
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IDA
retrieved
26 September 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IDA
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
determination method
IMP
5 references
retrieved
8 April 2019
stated in
Identification of a nucleolin binding site in human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Biochemical and biophysical analyses of recombinant forms of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
The domain organization of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
biological process
DNA topological change
determination method
IDA
IEA
IMP
8 references
retrieved
26 September 2017
stated in
Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
Biochemical and biophysical analyses of recombinant forms of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
Identification of a nucleolin binding site in human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
The domain organization of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
26 September 2017
stated in
The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387
determination method
IDA
DNA topological change
determination method
IBA
IDA
IEA
IMP
9 references
retrieved
8 April 2019
stated in
Identification of a nucleolin binding site in human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Biochemical and biophysical analyses of recombinant forms of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
The domain organization of human topoisomerase I
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IEA
retrieved
8 April 2019
stated in
The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I
GOA
curator
UniProt
UniProt protein ID
P11387
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387
determination method
IBA

Identifiers

MeSH descriptor ID
C528909
subject named as
TOP1 protein, human
0 references
PDB structure ID
 
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