Wikidata

(Q21130994)

English

Protein arginine methyltransferase 5

mammalian protein found in Homo sapiens

  • 72 kDa ICln-binding protein
  • HMT1 hnRNP methyltransferase-like 5
  • PRMT5
  • SKB1 homolog
  • histone-arginine N-methyltransferase PRMT5
  • protein arginine N-methyltransferase 5
  • SKB1Hs
  • shk1 kinase-binding protein 1 homolog
  • jak-binding protein 1
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No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
27 references
retrieved
1 January 2018
stated in
HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Human fetal globin gene expression is regulated by LYAR.
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130
GOA
curator
UniProt
UniProt protein ID
O14744
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of the human PRMT5:MEP50 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
A Y2H-seq approach defines the human protein methyltransferase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Arginine methylation controls growth regulation by E2F-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
srGAP2 Arginine Methylation Regulates Cell Migration and Cell Spreading through Promoting Dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
A novel WD repeat protein component of the methylosome binds Sm proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
retrieved
1 January 2018
stated in
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744
determination method
IPI
cell component
biological process
EC enzyme number
2.1.1.321
1 reference
stated in
ENZYME
retrieved
22 April 2020

Identifiers

Ensembl protein ID
 
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