Wikidata

(Q21133247)

English

TAR DNA binding protein

mammalian protein found in Homo sapiens

  • TAR DNA-binding protein 43
  • TAR DNA-binding protein-43
  • TARDBP
In more languages

Statements

molecular function
protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines
GOA
curator
UniProt
UniProt protein ID
Q13148
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
GOA
curator
UniProt
UniProt protein ID
Q13148
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
identical protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
retrieved
8 April 2019
stated in
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IPI
RNA binding
determination method
HDA
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13148
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IEA
retrieved
8 April 2019
stated in
Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
IBA
retrieved
8 April 2019
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q13148
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
HDA
retrieved
8 April 2019
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q13148
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13148
determination method
HDA
cell component
biological process

Identifiers

Ensembl protein ID
 
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