(Q21135310)

English

Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity

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scholarly article

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Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity (English)

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cannabinoid receptor

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author name string

Lisa K Brents

1

author given names

Lisa K

author last names

Brents

1 reference

16 August 2022

Emily E Reichard

2

author given names

Emily E

author last names

Reichard

1 reference

16 August 2022

Sarah M Zimmerman

3

author given names

Sarah M

author last names

Zimmerman

1 reference

16 August 2022

Jeffery H Moran

4

author given names

Jeffery H

author last names

Moran

1 reference

16 August 2022

William E Fantegrossi

5

author given names

William E

author last names

Fantegrossi

1 reference

16 August 2022

Paul L Prather

6

author given names

Paul L

author last names

Prather

1 reference

16 August 2022

language of work or name

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publication date

2011

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6

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7

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e21917

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copyright license

Creative Commons Attribution 4.0 International

6 July 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

19 March 2017

Withdrawal phenomena and dependence syndrome after the consumption of "spice gold"

1 reference

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19 March 2017

Activation of G-proteins in brain by endogenous and exogenous cannabinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

19 March 2017

Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

19 March 2017

Cannabinoid receptor localization in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

19 March 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

19 March 2017

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

19 March 2017

Chemical analysis of synthetic cannabinoids as designer drugs in herbal products

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19 March 2017

The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors

1 reference

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Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding

1 reference

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19 March 2017

Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine

1 reference

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The manifold actions of endocannabinoids on female and male reproductive events.

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Role of cannabinoids in the treatment of pain and (painful) spasticity

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12 September 2017

Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants

1 reference

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12 September 2017

Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Glutamatergic theories of schizophrenia.

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12 September 2017

Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Spice drugs as a new trend: mode of action, identification and legislation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Dopaminergic dysfunction in schizophrenia: salience attribution revisited.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Detection of JWH-018 metabolites in smoking mixture post-administration urine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Mutations in GABAA receptor subunits associated with genetic epilepsies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

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Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

Aminoalkylindoles: structure-activity relationships of novel cannabinoid mimetics

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

12 September 2017

"Spice" girls: synthetic cannabinoid intoxication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

27 September 2017

Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

27 September 2017

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

27 September 2017

Structure-activity relationships of indole- and pyrrole-derived cannabinoids

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130777

30 May 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs?

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

Identification of a cannabinoid analog as a new type of designer drug in a herbal product.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

In vitro phase I metabolism of the synthetic cannabimimetic JWH-018.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

Warning: legal synthetic cannabinoid-receptor agonists such as JWH-018 may precipitate psychosis in vulnerable individuals

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

Roles of β- and α2-adrenoceptors within the central nucleus of the amygdala in the visceral pain-induced aversion in rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021917

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29 November 2018

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29 November 2018

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https://pubmed.ncbi.nlm.nih.gov/21755008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21755008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21755008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21755008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0021917

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2011PLoSO...621917B

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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