(Q21135310)

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Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity

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scholarly article

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Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity (English)

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cannabinoid receptor

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author name string

Lisa K Brents

1

author given names

Lisa K

author last names

Brents

1 reference

PubMed publication ID

16 August 2022

Emily E Reichard

2

author given names

Emily E

author last names

Reichard

1 reference

PubMed publication ID

16 August 2022

Sarah M Zimmerman

3

author given names

Sarah M

author last names

Zimmerman

1 reference

PubMed publication ID

16 August 2022

Jeffery H Moran

4

author given names

Jeffery H

author last names

Moran

1 reference

PubMed publication ID

16 August 2022

William E Fantegrossi

5

author given names

William E

author last names

Fantegrossi

1 reference

PubMed publication ID

16 August 2022

Paul L Prather

6

author given names

Paul L

author last names

Prather

1 reference

PubMed publication ID

16 August 2022

language of work or name

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publication date

2011

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6

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7

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e21917

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copyright license

Creative Commons Attribution 4.0 International

6 July 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

1 reference

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Withdrawal phenomena and dependence syndrome after the consumption of "spice gold"

1 reference

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Activation of G-proteins in brain by endogenous and exogenous cannabinoids

1 reference

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Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations

1 reference

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Cannabinoid receptor localization in brain

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂

1 reference

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Chemical analysis of synthetic cannabinoids as designer drugs in herbal products

1 reference

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1 reference

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Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding

1 reference

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1 reference

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Spice drugs as a new trend: mode of action, identification and legislation

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1 reference

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Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders.

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21755008

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21755008

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21755008

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0021917

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2011PLoSO...621917B

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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