(Q37714086)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

review article

1 reference

title

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Giulia Curia

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Giuseppe Biagini

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

5

Massimo Avoli

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

David S Ragsdale

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

publication date

1 April 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

page(s)

413-424

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

High conductance sustained single-channel activity responsible for the low-threshold persistent Na(+) current in entorhinal cortex neurons.

21 January 2020

cites work

1 reference

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7 January 2021

Persistent sodium current in mammalian central neurons

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7 January 2021

Persistent Sodium Current and Its Role in Epilepsy

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7 January 2021

Molecular determinants for modulation of persistent sodium current by G-protein betagamma subunits.

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7 January 2021

Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels

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7 January 2021

General mechanisms of axonal damage and its prevention

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7 January 2021

Mechanisms of disease: sodium channels and neuroprotection in multiple sclerosis-current status

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7 January 2021

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

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7 January 2021

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

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7 January 2021

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

1 reference

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7 January 2021

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

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7 January 2021

Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels

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7 January 2021

Role of the C-terminal domain in inactivation of brain and cardiac sodium channels

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7 January 2021

Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins.

1 reference

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7 January 2021

Mechanisms of sodium channel inactivation

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7 January 2021

Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy

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7 January 2021

Sodium channel activity modulates multiple functions in microglia

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7 January 2021

Voltage-gated Na+ channels in glia: properties and possible functions

1 reference

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7 January 2021

Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter.

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7 January 2021

Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activity

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7 January 2021

On the cellular and network bases of epileptic seizures.

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7 January 2021

Induction of neonatal sodium channel II and III alpha-isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus.

1 reference

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7 January 2021

Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy

1 reference

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7 January 2021

Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Sodium currents in isolated rat CA1 pyramidal and dentate granule neurones in the post-status epilepticus model of epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Persistent sodium current in subicular neurons isolated from patients with temporal lobe epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities.

1 reference

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7 January 2021

Sodium channel mutations in epilepsy and other neurological disorders

1 reference

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7 January 2021

SCN1A mutations and epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

The spectrum of SCN1A-related infantile epileptic encephalopathies.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Epileptogenic channelopathies: experimental models of human pathologies.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Effects in neocortical neurons of mutations of the Na(v)1.2 Na+ channel causing benign familial neonatal-infantile seizures.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations.

1 reference

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7 January 2021

Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function.

1 reference

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7 January 2021

A functional null mutation of SCN1B in a patient with Dravet syndrome

1 reference

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7 January 2021

A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome

1 reference

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7 January 2021

A catalog of SCN1A variants

1 reference

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7 January 2021

Inherited disorders of voltage-gated sodium channels

1 reference

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7 January 2021

How do mutant Nav1.1 sodium channels cause epilepsy?

1 reference

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7 January 2021

A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Modulatory proteins can rescue a trafficking defective epileptogenic Nav1.1 Na+ channel mutant

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

A rescuable folding defective Nav1.1 (SCN1A) sodium channel mutant causes GEFS+: common mechanism in Nav1.1 related epilepsies?

1 reference

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7 January 2021

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Novel mutation confirms seizure locus SCN1A is also familial hemiplegic migraine locus FHM3

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Self-limited hyperexcitability: functional effect of a familial hemiplegic migraine mutation of the Nav1.1 (SCN1A) Na+ channel

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Divergent sodium channel defects in familial hemiplegic migraine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Mechanisms of migraine aura revealed by functional MRI in human visual cortex

1 reference

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7 January 2021

Familial hemiplegic migraine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Hyperexcitability, persistent Na+ conductances and neurodegeneration in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Voltage-gated sodium channel blockers for the treatment of neuropathic pain

1 reference

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7 January 2021

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

An SCN9A channelopathy causes congenital inability to experience pain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Fire and phantoms after spinal cord injury: Na+ channels and central pain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

The neurobiology of antiepileptic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Molecular pharmacodynamics, clinical therapeutics, and pharmacokinetics of topiramate

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Topiramate alters excitatory synaptic transmission in mouse hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Childhood absence epilepsy: genes, channels, neurons and networks.

1 reference

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7 January 2021

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Riluzole in the treatment of mood and anxiety disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Seeking a mechanism of action for the novel anticonvulsant lacosamide.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Sodium channel blockers and neuroprotection in multiple sclerosis using lamotrigine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Recent developments in multiple sclerosis therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Riluzole inhibits the persistent sodium current in mammalian CNS neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Voltage-gated sodium channels and hyperalgesia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Lacosamide: a review of preclinical properties.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Paroxysmal extreme pain disorder (previously familial rectal pain syndrome)

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

From genes to pain: Na v 1.7 and human pain disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Voltage-gated ion channels and gating modifier toxins.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Imidazopyridines: A novel class of hNav1.7 channel blockers

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2810%2970059-4

7 January 2021

10.1016/S1474-4422(10)70059-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20298965%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference