(Q34150830)

31 July 2017

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title

Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy (English)

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31 July 2017

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Wolfgang Löscher

1

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31 July 2017

publication date

1 January 2002

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31 July 2017

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31 July 2017

volume

16

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31 July 2017

issue

10

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31 July 2017

page(s)

669-694

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https://scigraph.springernature.com/pub.10.2165/00023210-200216100-00003

31 July 2017

exact match

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cites work

In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats

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Comparative pharmacodynamics and brain distribution of E-delta 2-valproate and valproate in rats.

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Progression and generalization of seizure discharge: anatomical and neurochemical substrates

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A risk-benefit assessment of therapies for Lennox-Gastaut syndrome

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Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine, and their metabolites in the rat brain: an in vivo microdialysis study

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12 December 2020

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Effects of anticonvulsants on the formation of gamma-hydroxybutyrate from gamma-aminobutyrate in rat brain.

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Effects of n-dipropylacetic acid (Depakine) on the activity of the cortical epileptic focus produced with cobalt

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Cyclic nucleotides and nervous system function

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Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

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Metabolite levels in brain following experimental seizures: the effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers

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12 December 2020

Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brain

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12 December 2020

The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates

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12 December 2020

Pharmacological, toxicological and neurochemical effects of delta 2(E)-valproate in animals

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A new benzodiazepine pharmacology.

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Valproate therapy for prevention of posttraumatic seizures: a randomized trial.

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The role of GABAB mechanisms in animal models of absence seizures

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12 December 2020

Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock

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12 December 2020

A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group

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12 December 2020

Neurophysiological and biochemical changes evoked by valproic acid in the central nervous system

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12 December 2020

Emerging insights into the genesis of epilepsy

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Possible mechanisms of valproate in migraine prophylaxis

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12 December 2020

Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group.

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12 December 2020

Valproate and carbamazepine increase prefrontal dopamine release by 5-HT1A receptor activation.

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12 December 2020

Effects of valproate on hyponeophagia in rats: competitive antagonism with picrotoxin and non-competitive antagonism with RO 15-1788.

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12 December 2020

Causes of epilepsy: contributions of the Rochester epidemiology project.

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12 December 2020

Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.

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12 December 2020

Valproate enhances GABA turnover in the substantia nigra

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12 December 2020

Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture.

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12 December 2020

Trans-2-en-valproic acid limits action potential firing frequency in mouse central neurons in cell culture.

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12 December 2020

Effect of anticonvulsant drugs on thalamo-cortical and hippocampo-cortical self-sustained after-discharges in the rat

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12 December 2020

Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures.

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12 December 2020

Valproic acid inhibits the depolarizing rectification in neurons of rat amygdala.

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12 December 2020

Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis

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12 December 2020

Benzodiazepine cross-tolerance in mice extends to sodium valproate.

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12 December 2020

The effects of sodium valproate on gamma-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice

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12 December 2020

Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites. Possible mechanism of anticonvulsant and toxic actions

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12 December 2020

Common anticonvulsants inhibit Ca2+ uptake and amino acid neurotransmitter release in vitro.

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12 December 2020

Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy

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12 December 2020

The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice.

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12 December 2020

Neuroplasticity and cellular resilience in mood disorders

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12 December 2020

Epileptiform discharges induced by combined application of bicuculline and 4-aminopyridine are resistant to standard anticonvulsants in slices of rats.

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12 December 2020

Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo

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12 December 2020

Electrophysiologic analysis of the actions of valproate on pyramidal neurons in the rat hippocampal slice.

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12 December 2020

Different mechanisms of protection against apoptosis by valproate and Li+

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12 December 2020

[Effects of di-n-propylacetate on audiogenic crises in mice]

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12 December 2020

GABA(A) receptor subtypes: dissecting their pharmacological functions

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12 December 2020

Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats

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12 December 2020

Distribution of valproate across the interface between blood and cerebrospinal fluid

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12 December 2020

Effect of valproic acid on [3H]diazepam and [3H]dihydropicrotoxinin binding sites at the benzodiazepine-GABA receptor-ionophore complex

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12 December 2020

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

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12 December 2020

[3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.

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12 December 2020

Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group

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12 December 2020

Short term effects of valproate on infantile spasms

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12 December 2020

gamma-Hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models.

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12 December 2020

Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy

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12 December 2020

GABA receptor alterations after chronic lithium administration. Comparison with carbamazepine and sodium valproate

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12 December 2020

Membrane-disordering potency and anticonvulsant action of valproic acid and other short-chain fatty acids.

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12 December 2020

On the mechanism of action of valproid acid

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12 December 2020

Effect of sodium n-dipropylacetate on audiogenic seizures and brain -aminobutyric acid level.

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12 December 2020

3HPhenytoin identifies a novel anticonvulsant-binding domain on voltage-dependent sodium channels

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12 December 2020

Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed

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12 December 2020

Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid.

1 reference

12 December 2020

A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group

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12 December 2020

A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: caspase-3 dependency

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12 December 2020

A multicentre comparative trial of sodium valproate and carbamazepine in paediatric epilepsy. The Paediatric EPITEG Collaborative Group

1 reference

12 December 2020

Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neurons.

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12 December 2020

Valproic Acid and Metabolites: Pharmacological and Toxicological Studies

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12 December 2020

A comparison of the effects of valproate and its major active metabolite E-2-en-valproate on single unit activity of substantia nigra pars reticulata neurons in rats

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12 December 2020

Influence of valproate and carbamazepine on symmetrical cortical penicillin foci in the rat

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12 December 2020

Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment

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12 December 2020

Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy

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12 December 2020

Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin

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12 December 2020

Does ammonia contribute to increased GABA-ergic neurotransmission in liver failure?

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12 December 2020

Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproate

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12 December 2020

Modifications by n-dipropylacetic acid (DPA) sodium salt of the activity of alumina induced cortico-motor epileptogenic foci

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12 December 2020

Valproate suppresses N-methyl-D-aspartate-evoked, transient depolarizations in the rat neocortex in vitro

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12 December 2020

Brain microdialysis of GABA and glutamate: what does it signify?

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12 December 2020

Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy.

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12 December 2020

A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy

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12 December 2020

'GABA shift' in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA.

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12 December 2020

Effects of valproate in a model nervous system (buccal ganglia of Helix pomatia): I. Antiepileptic actions.

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12 December 2020

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

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12 December 2020

Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices

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12 December 2020

In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities.

1 reference

12 December 2020

Suppression of preoptic GABA release caused by push-pull-perfusion with sodium valproate

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12 December 2020

Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal Fractions

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12 December 2020

Anticonflict action of sodium valproate. Interaction with convulsant benzodiazepine (Ro 5-3663) and imidazodiazepine (Ro 15-1788)

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12 December 2020

The mechanism of action of sodium valproate

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12 December 2020

Single pyramidal-tract fiber analysis of neocortical propagated seizures with reference to inactivation responses☆

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12 December 2020

Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy

1 reference

12 December 2020

Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism.

1 reference

12 December 2020

Recent advances in GABAB receptors: from pharmacology to molecular biology.

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12 December 2020

Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus

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12 December 2020

Valproate doubles the anoxic survival time of normal developing mice: possible relevance to valproate-induced decreases in cerebral levels of glutamate and aspartate, and increases in taurine

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12 December 2020

Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine.

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12 December 2020

Cellular compartments of GABA in brain and their relationship to anticonvulsant activity

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12 December 2020

Mechanism of anticonvulsant action of valproate

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12 December 2020

Valproate: Recent Findings and Perspectives

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12 December 2020

Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes

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12 December 2020

A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures

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12 December 2020

Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity

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12 December 2020

Effect of acute and chronic anticonvulsant administration on endogenous gamma-hydroxybutyrate in rat brain

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12 December 2020

Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

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12 December 2020

Effects of sodium valproate on mitochondrial membranes: electron paramagnetic resonance and transmembrane protein movement studies

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12 December 2020

Valproate enhances GABA-A mediated inhibition of locus coeruleus neurones in vitro

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12 December 2020

Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons.

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12 December 2020

Effect of anticonvulsants on thalamic afterdischarge in rats and cats

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12 December 2020

Pattern-and age-dependency of the antiepileptic effects induced by valproic acid in the rat hippocampus

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12 December 2020

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

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12 December 2020

The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis study

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12 December 2020

Anti-epileptic action of the sodium salt of N-dipropylacetic acid. Experimental study in the cat

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12 December 2020

Comparison of valproate and phenobarbital treatment after status epilepticus in rats.

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12 December 2020

Paroxysmal epileptiform discharges in temporal lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants

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12 December 2020

Anti-epileptic properties of sodium valproate in rat amygdaloid kindling [proceedings]

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12 December 2020

Anticonvulsant drug effects on spontaneous thalamocortical rhythms in vitro: valproic acid, clonazepam, and alpha-methyl-alpha-phenylsuccinimide

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12 December 2020

Monoamine and GABA metabolism and the anticonvulsant action of DI-n-propylacetate and ethanolamine-O-sulphate

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12 December 2020

Valproate and sodium currents in cultured hippocampal neurons.

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12 December 2020

Interactions between valproate, glutamate, aspartate, and GABA with respect to uptake in astroglial primary cultures

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12 December 2020

Dipropylacetic acid (Depakine) in experimental epilepsy in the alert cat

1 reference

12 December 2020

Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial

1 reference

12 December 2020

Unraveling the function of GABA(A) receptor subtypes.

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12 December 2020

Unusual interactions of benzodiazepine receptor antagonists.

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12 December 2020

Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis

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12 December 2020

Benzodiazepine antagonists abolish electrophysiological effects of sodium valproate in the rat

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12 December 2020

Evidence of stimulation of the gamma-aminobutyric acid shunt by valproate and E-delta 2-valproate in neonatal rat brain.

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12 December 2020

Lamotrigine-associated rash: risk/benefit considerations in adults and children

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12 December 2020

Effects of antiepileptic drugs on pentylenetetrazole-induced epileptiform activity in the in vitro hippocampus.

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12 December 2020

Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse

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12 December 2020

Comparison of effects of valproate and trans-2-en-valproate on different forms of epileptiform activity in rat hippocampal and temporal cortex slices.

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12 December 2020

Mechanisms of action of valproate: a commentatory

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12 December 2020

Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.

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12 December 2020

Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons

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12 December 2020

The new generation of GABA enhancers. Potential in the treatment of epilepsy

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12 December 2020

Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents

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12 December 2020

Actions and Interactions of Dipropylacetate and Penicillin on Evoked Potentials of Excised Prepiriform Cortex of Guinea Pig

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12 December 2020

Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons

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12 December 2020

Reversal of the anti-conflict action of valproate by various GABA and benzodiazepine antagonists

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12 December 2020

Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

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12 December 2020

Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy.

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12 December 2020

Valproate induced changes in GABA metabolism at the subcellular level

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12 December 2020

New visions in the pharmacology of anticonvulsion

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12 December 2020

Chlordiazepoxide and valproate enhancement of saline drinking by nondeprived rats: effects of bicuculline, picrotoxin and Ro15-1788.

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12 December 2020

Double-blind study on the anti-convulsive effect of phenobarbital and valproate in the Lennox syndrome

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12 December 2020

Changes in brain metabolites induced by convulsants or electroshock: effects of anticonvulsant agents

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12 December 2020

Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats

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12 December 2020

Marked increase in anticonvulsant activity but decrease in wet-dog shake behaviour during short-term treatment of amygdala-kindled rats with valproic acid

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12 December 2020

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds

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12 December 2020

Antiepileptic drugs as a cause of worsening seizures

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12 December 2020

Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons

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12 December 2020

Effect of sodium valproate on hypothalamic neurons in vivo and in vitro.

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12 December 2020

γ-Aminobutyric acid-ergic analgesia: Implications for γ-aminobutyric acid-ergic therapy for drug addictions

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12 December 2020

Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivo

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12 December 2020

Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group

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12 December 2020

Is the anticonvulsant mechanism of valproate linked to its interaction with the cerebral gamma-hydroxybutyrate system?

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12 December 2020

COMMUNICATION CONCERNING 1ST CLINICAL TESTS OF THE ANTICONVULSIVE ACTIVITY OF N-DIPROPYLACETIC ACID (SODIUM SALT)

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12 December 2020

Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin

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12 December 2020

Valproic acid differs in its in vitro effect on glutamic acid decarboxylase activity in neonatal and adult rat brain

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12 December 2020

10.2165/00023210-200216100-00003

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

1046120351

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