(Q33961525)

30 July 2017

1 reference

title

Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience (English)

1 reference

30 July 2017

1

Emilio Perucca

1 reference

30 July 2017

1 January 2002

1 reference

30 July 2017

1 reference

30 July 2017

16

1 reference

30 July 2017

695-714

1 reference

30 July 2017

10

1 reference

https://scigraph.springernature.com/pub.10.2165/00023210-200216100-00004

30 July 2017

0 references

cites work

Polycystic ovary syndrome: a changing perspective

1 reference

12 December 2020

Effect of valproate on free plasma phenytoin concentrations

1 reference

12 December 2020

Controlled trial of sodium valproate in severe epilepsy

1 reference

12 December 2020

Comparative study of ethosuximide and sodium valproate in the treatment of typical absence seizures (petit mal)

1 reference

12 December 2020

On the association between valproate and polycystic ovary syndrome: a response and an alternative view

1 reference

12 December 2020

Sodium valproate and valpromide: differential interactions with carbamazepine in epileptic patients

1 reference

12 December 2020

Effectiveness of first antiepileptic drug.

1 reference

12 December 2020

l-Carnitine Supplementation in Childhood Epilepsy: Current Perspectives

1 reference

12 December 2020

An economic appraisal of carbamazepine, lamotrigine, phenytoin and valproate as initial treatment in adults with newly diagnosed epilepsy

1 reference

12 December 2020

Malformations in Offspring of Women with Epilepsy: A Prospective Study

1 reference

12 December 2020

Pharmacokinetics of valproic acid in the elderly

1 reference

12 December 2020

Effect of valproic acid on spike and wave discharges in patients with absence seizures

1 reference

12 December 2020

A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group

1 reference

12 December 2020

Proceedings: The effect of sodium valproate (Epilim) on the EEG

1 reference

12 December 2020

[Intravenous valproic acid administration in status epilepticus]

1 reference

12 December 2020

Once-daily sodium valproate in the treatment of epilepsy

1 reference

12 December 2020

Interaction between phenytoin and valproic acid: plasma protein binding and metabolic effects

1 reference

12 December 2020

Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment

1 reference

12 December 2020

Harnessing the clinical potential of antiepileptic drug therapy: dosage optimisation

1 reference

12 December 2020

Prevalence of epilepsy in Rochester, Minnesota: 1940-1980.

1 reference

12 December 2020

Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.

1 reference

12 December 2020

Status epilepticus: current concepts

1 reference

12 December 2020

Disposition of sodium valproate in epileptic patients

1 reference

12 December 2020

Clinical experience of three pediatric and one adult case of spike-and-wave status epilepticus treated with injectable valproic acid

1 reference

12 December 2020

Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy

1 reference

12 December 2020

Pancreatitis associated with valproic acid: a review of the literature

1 reference

12 December 2020

Valproate-associated pancreatitis

1 reference

12 December 2020

Gastrointestinal adverse effects with divalproex sodium and valproic acid

1 reference

12 December 2020

Interaction of lamotrigine with sodium valproate

1 reference

12 December 2020

The importance of drug interactions in epilepsy therapy

1 reference

12 December 2020

Pregnancy registries in epilepsy

1 reference

12 December 2020

Prevention of recurrent febrile convulsions--a randomized therapeutic assay: sodium valproate, phenobarbital and placebo

1 reference

12 December 2020

Evaluation of drug treatment outcome in epilepsy: a clinical perspective

1 reference

12 December 2020

Sodium valproate: monotherapy and polytherapy

1 reference

12 December 2020

Valproate prevents the recurrence of absence status

1 reference

12 December 2020

Is valproate pharmacotherapy associated with polycystic ovaries?

1 reference

12 December 2020

On the association between valproate and polycystic ovary syndrome

1 reference

12 December 2020

Monotherapy with valproate in primary generalized epilepsies

1 reference

12 December 2020

The management of epilepsy in the 1990s. Acquisitions, uncertainties and priorities for future research

1 reference

12 December 2020

Adding valproate to lamotrigine: a study of their pharmacokinetic interaction

1 reference

12 December 2020

Distribution of valproate across the interface between blood and cerebrospinal fluid

1 reference

12 December 2020

Valproic acid disposition and protein binding in pregnancy

1 reference

12 December 2020

Valproate-associated pancreatitis and cholecystitis in six mentally retarded adults.

1 reference

12 December 2020

Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment

1 reference

12 December 2020

Pharmacokinetic interaction between zidovudine and valproic acid in patients infected with human immunodeficiency virus

1 reference

12 December 2020

Low and variable presence of valproic acid in human brain

1 reference

12 December 2020

Valproic acid: in vitro plasma protein binding and interaction with phenytoin

1 reference

12 December 2020

Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group

1 reference

12 December 2020

Intravenous valproate treatment of generalized nonconvulsive status epilepticus

1 reference

12 December 2020

Sodium valproate versus phenobarbital in the prophylactic treatment of febrile convulsions in childhood.

1 reference

12 December 2020

Additional educational needs in children born to mothers with epilepsy

1 reference

12 December 2020

Valproic acid versus ethosuximide in the treatment of absence seizures

1 reference

12 December 2020

Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine

1 reference

12 December 2020

Valproate, carnitine metabolism, and biochemical indicators of liver function. Collaborative Group for the Study of Epilepsy

1 reference

12 December 2020

The safety of rapid valproic acid infusion

1 reference

12 December 2020

Guidelines for therapeutic monitoring on antiepileptic drugs. Commission on Antiepileptic Drugs, International League Against Epilepsy

1 reference

12 December 2020

A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group

1 reference

12 December 2020

A multicentre comparative trial of sodium valproate and carbamazepine in paediatric epilepsy. The Paediatric EPITEG Collaborative Group

1 reference

12 December 2020

Which drug for the adult epileptic patient: phenytoin or valproate?

1 reference

12 December 2020

A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy

1 reference

12 December 2020

Comparison of phenobarbitone, phenytoin with sodium valproate: randomized, double-blind study

1 reference

12 December 2020

Kinetics of penetration of common antiepileptic drugs into cerebrospinal fluid

1 reference

12 December 2020

Valproic acid dosage and plasma protein binding and clearance

1 reference

12 December 2020

Impact of valproate and phenytoin on cognitive function in elderly patients: results of a single-blind randomized comparative study.

1 reference

12 December 2020

Valproic Acid-Induced Neural Tube Defects in Mouse and Human: Aspects of Chirality, Alternative Drug Development, Pharmacokinetics and Possible Mechanisms

1 reference

12 December 2020

Anticonvulsant drugs and cognitive functions.

1 reference

12 December 2020

Sodium Valproate, Serum Level and Clinical Effect in Epilepsy: A Controlled Study

1 reference

12 December 2020

A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy

1 reference

12 December 2020

Hematologic toxicity of sodium valproate

1 reference

12 December 2020

On the toxicity of valproic-acid.

1 reference

12 December 2020

Randomised controlled trials of phenobarbitone and valproate in febrile convulsions

1 reference

12 December 2020

Valproic acid disposition in epileptic patients during combined antiepileptic maintenance therapy

1 reference

12 December 2020

Adverse effects of valproate.

1 reference

12 December 2020

Plasma concentrations of valproate during maintenance therapy in epileptic children

1 reference

12 December 2020

Intravenous valproate dosing in neonates

1 reference

12 December 2020

Valproate versus carbamazepine for seizures

1 reference

12 December 2020

Treatment of Infantile Spasms with Sodium Dipropylacetic Acid

1 reference

12 December 2020

Management issues for women with epilepsy: a review of the literature.

1 reference

12 December 2020

Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy

1 reference

12 December 2020

Teratogenic effects of antiepileptic drugs: implications for the management of epilepsy in women of childbearing age.

1 reference

12 December 2020

Seizure-inducing effects of antiepileptic drugs: a review

1 reference

12 December 2020

The role of carnitine supplementation during valproic acid therapy

1 reference

12 December 2020

Valproic acid suppresses the synaptic response mediated by the NMDA receptors in rat amygdalar slices.

1 reference

12 December 2020

The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction.

1 reference

12 December 2020

Congenital malformations due to antiepileptic drugs

1 reference

12 December 2020

Clinical study of lamotrigine and valproic acid in patients with epilepsy: using a drug interaction to advantage?

1 reference

12 December 2020

Effects of divalproex sodium on amitriptyline and nortriptyline pharmacokinetics

1 reference

12 December 2020

Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy

1 reference

12 December 2020

Antiepileptic drug regimens and major congenital abnormalities in the offspring

1 reference

12 December 2020

Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities.

1 reference

12 December 2020

Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain

1 reference

12 December 2020

Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

1 reference

12 December 2020

Drug interactions with valproic acid

1 reference

12 December 2020

Therapy of infantile spasms with valproate: results of a prospective study

1 reference

12 December 2020

Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy

1 reference

12 December 2020

Valproate in the treatment of absence epilepsy in children: a study of dose-response relationships

1 reference

12 December 2020

Valproic acid hepatic fatalities. II. US experience since 1984.

1 reference

12 December 2020

Pharmacological principles as a basis for polytherapy

1 reference

12 December 2020

Clinical and pharmacokinetic observations on sodium valproate - a 5-year follow-up study in 100 children with epilepsy.

1 reference

12 December 2020

Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy

1 reference

12 December 2020

In-utero exposure to valproate and neural tube defects.

1 reference

12 December 2020

Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis

1 reference

12 December 2020

Lorazepam-valproate interaction: studies in normal subjects and isolated perfused rat liver

1 reference

12 December 2020

Serum concentrations of valproic acid: influence of dose and comedication

1 reference

12 December 2020

Valproate-ethosuximide combination therapy for refractory absence seizures

1 reference

12 December 2020

Intravenous valproate is well tolerated in unstable patients with status epilepticus

1 reference

12 December 2020

Effectiveness and toxicity of phenobarbital, primidone, and sodium valproate in the prevention of febrile convulsions, controlled by plasma levels

1 reference

12 December 2020

Weight gain during treatment with valproate.

1 reference

12 December 2020

Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy.

1 reference

12 December 2020

Treatment of absence status with intravenous valproate

1 reference

12 December 2020

Clinical pharmacokinetics of valproic acid--1988.

1 reference

12 December 2020

A comparison of phenytoin and valproate in previously untreated adult epileptic patients

1 reference

12 December 2020

Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial

1 reference

12 December 2020

Valproate sodium: a controlled clinical trial including monitoring of drug levels

1 reference

12 December 2020

Use of Valproic Acid in Treatment of Infantile Spasms

1 reference

12 December 2020

Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients

1 reference

12 December 2020

Valproate versus carbamazepine for seizures

1 reference

12 December 2020

Valproate and the polycystic ovarian syndrome: final thoughts

1 reference

12 December 2020

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

1 reference

12 December 2020

Clinical and economic impact of replacing divalproex sodium with valproic acid.

1 reference

12 December 2020

Clinical pharmacokinetics of valproic acid

1 reference

12 December 2020

Cost minimization analysis of antiepileptic drugs in newly diagnosed epilepsy in 12 European countries.

1 reference

12 December 2020

Influence of food intake on the pharmacokinetics of a sustained release formulation of sodium valproate.

1 reference

12 December 2020

Altered ovarian function and cardiovascular risk factors in valproate-treated women

1 reference

12 December 2020

Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

1 reference

12 December 2020

Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients

1 reference

12 December 2020

The effect of valproic acid on blood loss in patients with cerebral palsy

1 reference

12 December 2020

Meal-dependent absorption of enteric-coated sodium valproate.

1 reference

12 December 2020

Antiepileptic drugs as a cause of worsening seizures

1 reference

12 December 2020

Monotherapy trials with the new antiepileptic drugs: study designs, practical relevance and ethical implications

1 reference

12 December 2020

Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus

1 reference

12 December 2020

Valproic acid hepatic fatalities. III. U.S. experience since 1986.

1 reference

12 December 2020

Refractory idiopathic absence status epilepticus: A probable paradoxical effect of phenytoin and carbamazepine

1 reference

12 December 2020

Valproic acid-ethosuximide interaction: a pharmacokinetic study

1 reference

12 December 2020

Valproic acid and plasma levels of phenobarbital

1 reference

12 December 2020

Practice parameter: long-term treatment of the child with simple febrile seizures. American Academy of Pediatrics. Committee on Quality Improvement, Subcommittee on Febrile Seizures

1 reference

12 December 2020

Assessing risk to benefit ratio in antiepileptic drug therapy

1 reference

12 December 2020

A comment on the efficacy of valproate in the treatment of partial seizures

1 reference

12 December 2020

The teratogenicity of anticonvulsant drugs

1 reference

12 December 2020

Safety and efficacy of divalproex sodium monotherapy in partial epilepsy: a double-blind, concentration-response design clinical trial. Depakote Monotherapy for Partial Seizures Study Group

1 reference

12 December 2020

Teratogenicity of antiepileptic drug combinations with special emphasis on epoxidation (of carbamazepine)

1 reference

12 December 2020

Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group

1 reference

12 December 2020

10.2165/00023210-200216100-00004

Identifiers

DOI

1 reference

PubMed ID

12269862

Dimensions Publication ID

30 July 2017

0 references

1 reference

PubMed ID

12269862