(Q37011415)

English

Valproic Acid-Induced Neural Tube Defects in Mouse and Human: Aspects of Chirality, Alternative Drug Development, Pharmacokinetics and Possible Mechanisms

scientific article published on November 1, 1991

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scholarly article

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Europe PubMed Central

PubMed publication ID

17 August 2017

1 reference

Europe PubMed Central

Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Valproic Acid-Induced Neural Tube Defects in Mouse and Human: Aspects of Chirality, Alternative Drug Development, Pharmacokinetics and Possible Mechanisms (English)

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

author name string

H. Nau

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1803343

29 November 2022

R. S. Hauck

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1803343

29 November 2022

K. Ehlers

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1803343

29 November 2022

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1803343

29 November 2022

publication date

1 November 1991

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

full work available at URL

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0773.1991.tb01303.x

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1600-0773.1991.tb01303.x/fullpdf

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Basic and Clinical Pharmacology and Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

69

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

310-321

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Valproic acid hepatic fatalities: a retrospective review

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.1991.TB01303.X

21 January 2018

Valproate-associated hepatotoxicity and its biochemical mechanisms

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0773.1991.TB01303.X

21 January 2018

Verification of the fetal valproate syndrome phenotype

1

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid

2

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats

3

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Effect of chronic valproate treatment on folate-dependent methyl biosynthesis in the rat

4

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Valproic acid prenatal exposure. Association with lipomyelomeningocele

5

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content

6

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?

8

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

The embryonic development of mammalian neural tube defects.

9

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Developmental toxicity of valproic acid

10

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Anticonvulsants, folate levels, and pregnancy outcome: a prospective study

11

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Marked accumulation of valproic acid in embryonic neuroepithelium of the mouse during early organogenesis

12

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

The fetal valproate syndrome

13

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Valproic acid-induced spina bifida: a mouse model

16

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite.

18

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

20

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Phenytoin teratogenicity and effects on embryonic and maternal folate metabolism [published errtum appears in Teratology 1986 Dec;34(3):487]

22

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid

23

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

[Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].

24

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate

25

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

On the development of alternative antiepileptic drugs

27

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10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

The effects of carbamazepine and valproate on folate metabolism in man

28

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10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Valproic acid developmental toxicity and pharmacokinetics in the rhesus monkey: an interspecies comparison

29

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Congenital malformations associated with maternal use of valproic acid

30

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10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid

31

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10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects

33

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture

34

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

In-utero exposure to valproate and neural tube defects.

35

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Pharmacological evaluation of various metabolites and analogues of valproic acid. Anticonvulsant and toxic potencies in mice

36

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy

37

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Clinical manifestation of prenatal exposure to valproic acid using case reports and epidemiologic information

38

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Predicting the human teratogenic potential of the anticonvulsant, valproic acid, from a non-human primate model

39

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

New animal model for the study of neural tube defects

41

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

The development of the human brain, the closure of the caudal neuropore, and the beginning of secondary neurulation at stage 12.

42

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Teratogenic valproic acid concentrations: infusion by implanted minipumps vs conventional injection regimen in the mouse

43

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Species differences in pharmacokinetics and drug teratogenesis

44

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen

45

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse

46

1 reference

10.1111/J.1600-0773.1991.TB01303.X

https://api.crossref.org/works/10.1111/J.1600-0773.1991.TB01303.X

29 November 2022

Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice

47

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo

48

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Teratogenicity of valproic acid and related substances in the mouse: drug accumulation and pHi in the embryo during organogenesis and structure-activity considerations

50

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10.1111/J.1600-0773.1991.TB01303.X

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A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

52

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Anticonvulsant activity and embryotoxicity of valproic acid

53

1 reference

10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Pharmacokinetic aspects of drug effects in vitro (II) placental transfer to the embryo and activity of some carboxylic acids structurally related to valproic acid in whole embryos in culture

54

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Folate antagonism following teratogenic exposure to diphenylhydantoin

55

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Serum folic acid levels in epileptic mothers and their relationship to congenital malformations

56

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Teratogenesis of calcium valproate in rats

57

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Teratogenesis of calcium valproate in rabbits

58

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Valproate and birth defects

59

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Maternal valproic acid and congenital neural tube defects

60

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10.1111/J.1600-0773.1991.TB01303.X

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Reduction of embryonic intracellular pH: a potential mechanism of acetazolamide-induced limb malformations

63

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Neural tube defects: are neurulation and canalization forms causally distinct?

64

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29 November 2022

Neural-tube defects and derangement of homocysteine metabolism

66

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Possible causal heterogeneity in spina bifida cystica

67

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Valproic acid-induced neural tube defects: reduction by folinic acid in the mouse

68

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate

69

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Teratogenicity and developmental toxicity of valproic acid in rats

70

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Lack of teratogenicity of trans-2-ene-valproic acid compared to valproic acid in rats.

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10.1111/J.1600-0773.1991.TB01303.X

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29 November 2022

Effect of valproate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets.

72

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29 November 2022

Diurnal variation of folate concentrations in mouse embryo and plasma: The protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent

73

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29 November 2022

Zinc concentrations in mouse embryo and maternal plasma. Effect of valproic acid and nonteratogenic metabolite

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29 November 2022

Identifiers

10.1111/J.1600-0773.1991.TB01303.X

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

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