(Q35172793)

6 August 2017

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title

Mechanisms of sodium channel inactivation (English)

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6 August 2017

1

Alan L Goldin

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6 August 2017

1 June 2003

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Current Opinion in Neurobiology

6 August 2017

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6 August 2017

13

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6 August 2017

3

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6 August 2017

284-290

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From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A role for phosphorylation in the maintenance of resurgent sodium current in cerebellar purkinje neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Solution structure of the sodium channel inactivation gate

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Structural study of the sodium channel inactivation gate peptide including an isoleucine-phenylalanine-methionine motif and its analogous peptide (phenylalanine/glutamine) in trifluoroethanol solutions and SDS micelles

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Solution structures of the inactivation gate particle peptides of rat brain type-IIA and human heart sodium channels in SDS micelles

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Solution structures of the cytoplasmic linkers between segments S4 and S5 (S4-S5) in domains III and IV of human brain sodium channels in SDS micelles

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Role in fast inactivation of the IV/S4-S5 loop of the human muscle Na+ channel probed by cysteine mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Interaction between the sodium channel inactivation linker and domain III S4-S5.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Molecular modeling and dynamics of the sodium channel inactivation gate

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Molecular analysis of potential hinge residues in the inactivation gate of brain type IIA Na+ channels

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Dynamic rearrangement of the outer mouth of a K+ channel during gating

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Role of domain 4 in sodium channel slow inactivation

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

The selectivity filter of the voltage-gated sodium channel is involved in channel activation

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Implication of the C-terminal region of the alpha-subunit of voltage-gated sodium channels in fast inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Role of the C-terminal domain in inactivation of brain and cardiac sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Congenital long-QT syndrome caused by a novel mutation in a conserved acidic domain of the cardiac Na+ channel.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Secondary structure of the human cardiac Na+ channel C terminus: evidence for a role of helical structures in modulation of channel inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

The human heart and rat brain IIA Na+ channels interact with different molecular regions of the beta1 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Modulation of Na+ channel inactivation by the beta 1 subunit: a deletion analysis.

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

The extracellular domain of the beta1 subunit is both necessary and sufficient for beta1-like modulation of sodium channel gating.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Tissue distribution and functional expression of the human voltage-gated sodium channel beta3 subunit

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta3, in rat CNS.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

The sodium channel -subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Auxiliary subunits of voltage-gated ion channels

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Spectrum of sodium channel disturbances in the nondystrophic myotonias and periodic paralyses

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Inherited sodium channelopathies: models for acquired arrhythmias?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

1 reference

7 January 2021

Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A novel mechanism associated with idiopathic ventricular fibrillation (IVF) mutations R1232W and T1620M in human cardiac sodium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Generalized epilepsy with febrile seizures plus: mutation of the sodium channel subunit SCN1B.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus--and prevalence of variants in patients with epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Nav1.1 mutations cause febrile seizures associated with afebrile partial seizures

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Frequent mutations of SCN1A in severe myoclonic epilepsy in infancy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Skeletal muscle sodium channel is affected by an epileptogenic beta1 subunit mutation

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Modulation of sodium current in mammalian cells by an epilepsy-correlated beta 1-subunit mutation

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https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Enhanced inactivation and acceleration of activation of the sodium channel associated with epilepsy in man

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Generalized epilepsy with febrile seizures plus type 2 mutation W1204R alters voltage-dependent gating of Na(v)1.1 sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Molecular basis of an inherited epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

A double mutation in families with periodic paralysis defines new aspects of sodium channel slow inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

The human skeletal muscle Na channel mutation R669H associated with hypokalemic periodic paralysis enhances slow inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2803%2900065-5

7 January 2021

10.1016/S0959-4388(03)00065-5

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12850212