(Q21135631)

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

membrane proteins

1 reference

inferred from GOA cell component → membrane

Laminin G domain, protein family

1 reference

Follistatin-like, N-terminal domain, protein family

1 reference

Leucine-rich repeat N-terminal domain, protein family

1 reference

Cystine knot, C-terminal domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

protein homodimerization activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

Structure and functional relevance of the Slit2 homodimerization domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

1 reference

9 May 2019

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

identical protein binding

1 reference

9 May 2019

Structure and functional relevance of the Slit2 homodimerization domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

3 references

8 April 2019

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

8 April 2019

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

8 April 2019

Structural insights into the Slit-Robo complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

1 reference

9 May 2019

Characterization of Slit protein interactions with glypican-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

4 references

9 May 2019

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Structural insights into the Slit-Robo complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

1 reference

9 May 2019

Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

1 reference

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

1 reference

17 October 2017

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94813&geneProductId=UniProtKB:O94813

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

extracellular exosome

1 reference

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

3 references

9 May 2019

The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of protein phosphorylation

IBA

biological process

1 reference

9 May 2019

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of chemokine-mediated signaling pathway

1 reference

9 May 2019

SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of neutrophil chemotaxis

1 reference

9 May 2019

The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of cellular response to growth factor stimulus

1 reference

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

1 reference

9 May 2019

Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site

ureteric bud development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of actin filament polymerization

1 reference

9 May 2019

The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of small GTPase mediated signal transduction

1 reference

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of retinal ganglion cell axon guidance

1 reference

9 May 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of mononuclear cell migration

1 reference

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

corticospinal neuron axon guidance through spinal cord

1 reference

9 May 2019

Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of smooth muscle cell migration

1 reference

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

positive regulation of axonogenesis

1 reference

9 May 2019

Slit2-Mediated chemorepulsion and collapse of developing forebrain axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

nervous system development

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

cell migration involved in sprouting angiogenesis

1 reference

9 May 2019

HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of endothelial cell migration

1 reference

9 May 2019

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of smooth muscle cell chemotaxis

1 reference

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

cellular response to hormone stimulus

1 reference

9 May 2019

Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of cell migration

IEP

negative regulation of monocyte chemotaxis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of cell growth

ISS

1 reference

17 October 2017

SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94813&geneProductId=UniProtKB:O94813

1 reference

9 May 2019

Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

apoptotic process involved in luteolysis

IEP

1 reference

9 May 2019

Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

positive regulation of apoptotic process

IEP

1 reference

9 May 2019

Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

induction of negative chemotaxis

1 reference

9 May 2019

Slit2-Mediated chemorepulsion and collapse of developing forebrain axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

cellular response to heparin

1 reference

9 May 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

motor neuron axon guidance

1 reference

9 May 2019

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

branching morphogenesis of an epithelial tube

negative regulation of leukocyte chemotaxis

1 reference

9 May 2019

The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

chemorepulsion involved in postnatal olfactory bulb interneuron migration

1 reference

9 May 2019

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

axon extension involved in axon guidance

1 reference

9 May 2019

Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of lamellipodium assembly

1 reference

9 May 2019

Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of vascular permeability

1 reference

9 May 2019

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

negative regulation of GTPase activity

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

aortic valve morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

pulmonary valve morphogenesis

ISS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

retinal ganglion cell axon guidance

ISS

3 references

9 May 2019

Slit2 is a repellent for retinal ganglion cell axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Structure and functional relevance of the Slit2 homodimerization domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

ventricular septum morphogenesis

IBA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

3 references

9 May 2019

The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94813

EGF-type aspartate/asparagine hydroxylation site

IBA

has part(s)

1 reference

EGF-like calcium-binding, conserved site

1 reference

cysteine-rich flanking region, C-terminal

1 reference

leucine-rich repeat N-terminal domain

1 reference

leucine-rich repeat, typical subtype

1 reference

Cystine knot, C-terminal

1 reference

Laminin G domain

1 reference

EGF-like, conserved site

1 reference

Leucine-rich repeat

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like domain

1 reference

follistatin-like, N-terminal

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016