(Q21135644)

English

SMCR8-C9orf72 complex subunit

mammalian protein found in Homo sapiens

SMCR8
guanine nucleotide exchange protein SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
smith-Magenis syndrome chromosomal region candidate gene 8 protein

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Statements

1 reference

13 November 2019

1 reference

1 December 2016

Folliculin/SMCR8, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Folliculin/SMCR8, tripartite DENN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

5 references

8 April 2019

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

8 April 2019

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

8 April 2019

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IPI

protein kinase inhibitor activity

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

protein kinase binding

1 reference

8 April 2019

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IPI

guanyl-nucleotide exchange factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IDA

guanyl-nucleotide exchange factor complex

1 reference

8 April 2019

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IDA

Atg1/ULK1 kinase complex

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

8 April 2019

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IEA

biological process

negative regulation of protein kinase activity

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

negative regulation of gene expression

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

negative regulation of macroautophagy

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

positive regulation of TOR signaling

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

positive regulation of autophagosome maturation

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

negative regulation of autophagosome assembly

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

regulation of TORC1 signaling

1 reference

8 April 2019

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IMP

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEV9&geneProductId=UniProtKB:Q8TEV9

determination method

IEA

regulation of transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEV9&geneProductId=UniProtKB:Q8TEV9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method

IEA

has part(s)

Folliculin/SMCR8, N-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8TEV9

Folliculin/SMCR8, tripartite DENN domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8TEV9

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

(Q21135644)

SMCR8-C9orf72 complex subunit

Statements

Identifiers

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