(Q21139609)

single-stranded DNA binding

1 reference

27 March 2018

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUW8&geneProductId=UniProtKB:Q9NUW8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

double-stranded DNA binding

1 reference

27 March 2018

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUW8&geneProductId=UniProtKB:Q9NUW8

3'-tyrosyl-DNA phosphodiesterase activity

4 references

27 March 2018

Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUW8&geneProductId=UniProtKB:Q9NUW8

27 March 2018

Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUW8&geneProductId=UniProtKB:Q9NUW8

27 March 2018

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUW8&geneProductId=UniProtKB:Q9NUW8

27 March 2018

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUW8&geneProductId=UniProtKB:Q9NUW8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

1 reference

8 April 2019

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

3'-tyrosyl-DNA phosphodiesterase activity

5 references

8 April 2019

Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

double-strand break repair

IBA

biological process

1 reference

27 March 2018

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUW8&geneProductId=UniProtKB:Q9NUW8

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

nucleic acid phosphodiester bond hydrolysis

1 reference

8 April 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

cellular response to DNA damage stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

single strand break repair

3 references

8 April 2019

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUW8

double-strand break repair

IBA

IBA

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016