(Q21146988)

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Werner Syndrome

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Werner Syndrome (English)

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Lishan Chen

1

author given names

Lishan

author last names

Chen

1 reference

PubMed publication ID

18 August 2022

Junko Oshima

2

author given names

Junko

author last names

Oshima

1 reference

PubMed publication ID

18 August 2022

publication date

2002

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Journal of Biomedicine and Biotechnology

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2

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2

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46-54

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copyright license

Creative Commons Attribution 3.0 Unported

1 January 2002

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April 2022 Public Data File from Crossref

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Werner protein recruits DNA polymerase delta to the nucleolus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Characterization of the human and mouse WRN 3'-->5' exonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Functional and physical interaction between WRN helicase and human replication protein A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

p53-mediated apoptosis is attenuated in Werner syndrome cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

The Werner syndrome protein is a DNA helicase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

The Bloom's syndrome gene product is homologous to RecQ helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Functional interaction between Ku and the werner syndrome protein in DNA end processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

WRN mutations in Werner syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Excess of rare cancers in Werner syndrome (adult progeria)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

19 March 2017

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

DNA double strand break repair in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

WRN helicase expression in Werner syndrome cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Physical and functional interaction between p53 and the Werner's syndrome protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

The Werner syndrome protein is involved in RNA polymerase II transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Reconsideration of senescence, immortalization and telomere maintenance of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Replication focus-forming activity 1 and the Werner syndrome gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

12 September 2017

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

Immunological diagnosis of Werner syndrome by down-regulated and truncated gene products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

27 September 2017

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

30 May 2018

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

30 May 2018

Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

29 November 2018

The Werner syndrome gene and global sequence variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

29 November 2018

Atypical osteosarcomas in Werner Syndrome (adult progeria).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

29 November 2018

Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

29 November 2018

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153784

29 November 2018

Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of Werner's syndrome heterozygotes in Japan

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A polymorphic variant C1367R of the Werner helicase gene and atherosclerotic diseases in the Japanese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism of Werner helicase-associated gene in long-term hemodialysis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variegated translocation mosaicism in human skin fibroblast cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of osteoporosis in a patient with Werner's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positional cloning of the Werner's syndrome gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Premature aging in Werner's syndrome spares the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous and compound heterozygous mutations at the Werner syndrome locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of helicase gene mutations in Japanese Werner's syndrome patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of methods for identifying transcription units and transcription map of the Werner syndrome gene region

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional activation by the Werner syndrome gene product in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/12488583

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1155/S1110724302201011

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