Wikidata

(Q21151769)

English

S-phase kinase associated protein 2

mammalian protein found in Homo sapiens

  • F-box protein Skp2
  • F-box/LRR-repeat protein 1
  • SKP2
  • S-phase kinase-associated protein 2
  • CDK2/cyclin A-associated protein p45
  • p45skp2
  • S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
  • Cyclin-A/CDK2-associated protein p45
  • SKP2 protein, human
In more languages

Statements

molecular function
protein binding
determination method
IPI
20 references
retrieved
1 January 2018
stated in
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
GOA
curator
UniProt
UniProt protein ID
Q13309
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway
GOA
curator
UniProt
UniProt protein ID
Q13309
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Acetylation-dependent regulation of Skp2 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
TIP120A associates with cullins and modulates ubiquitin ligase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
retrieved
1 January 2018
stated in
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13309
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
C000628447
subject named as
SKP2 protein, human
0 references
 
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