(Q21172627)

http://www.ebi.ac.uk/interpro/protein/Q5QJU3

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

13 November 2019

1 reference

13 November 2019

dihydroceramidase activity

1 reference

7 November 2018

Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5QJU3&geneProductId=UniProtKB:Q5QJU3

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

N-acylsphingosine amidohydrolase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

dihydroceramidase activity

3 references

8 April 2019

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

integral component of Golgi membrane

cell component

1 reference

8 April 2019

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

2 references

positive regulation of cell death

1 reference

8 April 2019

Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

response to retinoic acid

1 reference

8 April 2019

Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

ceramide metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

sphingosine biosynthetic process

3 references

7 November 2018

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5QJU3&geneProductId=UniProtKB:Q5QJU3

7 November 2018

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5QJU3&geneProductId=UniProtKB:Q5QJU3

7 November 2018

Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5QJU3&geneProductId=UniProtKB:Q5QJU3

sphingolipid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

negative regulation of cell-matrix adhesion

TAS

1 reference

8 April 2019

Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

positive regulation of cell population proliferation

1 reference

8 April 2019

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

negative regulation of cell adhesion mediated by integrin

1 reference

8 April 2019

Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

cellular response to DNA damage stimulus

1 reference

8 April 2019

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation

regulation of autophagy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

DNA damage response, signal transduction by p53 class mediator

regulation of apoptotic process

3 references

8 April 2019

Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

sphingosine biosynthetic process

5 references

8 April 2019

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

8 April 2019

Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3

ceramide catabolic process

sphingolipid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3