(Q47681263)

26 June 2018

title

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. (English)

1 reference

26 June 2018

main subject

Alkaline ceramidase 2

1 reference

regulation of apoptotic process

GOA release 2020-03-11

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GOA release 2020-03-11

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6

Yusuf A Hannun

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26 June 2018

author name string

Ruijuan Xu

1

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26 June 2018

Monica Garcia-Barros

2

1 reference

26 June 2018

Sally Wen

3

1 reference

26 June 2018

Fang Li

4

1 reference

26 June 2018

Chih-Li Lin

5

1 reference

26 June 2018

Lina M Obeid

7

1 reference

26 June 2018

Cungui Mao

8

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26 June 2018

publication date

11 December 2017

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26 June 2018

Cell Death & Differentiation

published in

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26 June 2018

volume

25

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26 June 2018

issue

5

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26 June 2018

page(s)

841-856

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26 June 2018

https://scigraph.springernature.com/pub.10.1038/s41418-017-0018-y

exact match

0 references

cites work

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

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30 June 2018

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Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

30 June 2018

1 reference

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The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

30 June 2018

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30 June 2018

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30 June 2018

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Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidative damage and mitochondrial fission

30 June 2018

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Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

30 June 2018

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30 June 2018

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Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest

30 June 2018

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Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase

30 June 2018

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Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

30 June 2018

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Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells

30 June 2018

1 reference

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Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.

30 June 2018

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A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy

30 June 2018

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Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)

30 June 2018

1 reference

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Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis

30 June 2018

1 reference

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The expanding universe of p53 targets

30 June 2018

1 reference

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Mitochondrial dynamics and apoptosis

30 June 2018

1 reference

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De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

30 June 2018

1 reference

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Principles of bioactive lipid signalling: lessons from sphingolipids

30 June 2018

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Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

30 June 2018

1 reference

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Autocrine and paracrine roles of sphingosine-1-phosphate

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Cellular senescence: when bad things happen to good cells

30 June 2018

1 reference

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p53 in health and disease

30 June 2018

1 reference

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The machines that divide and fuse mitochondria

30 June 2018

1 reference

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Evaluation of sphinganine and sphingosine as human breast cancer chemotherapeutic and chemopreventive agents

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Emerging functions of mammalian mitochondrial fusion and fission

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

The complex life of simple sphingolipids

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Processing of gene expression data generated by quantitative real-time RT-PCR.

30 June 2018

1 reference

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

p53-dependent ceramide response to genotoxic stress

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943524

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

14 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41418-017-0018-Y

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41418-017-0018-Y

1 reference

26 June 2018

Dimensions Publication ID

0 references

1 reference

26 June 2018

PubMed ID

29229990

1 reference

26 June 2018