(Q28265743)

Gene Ontology release 2020-05-02

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Yusuf A Hannun

1

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Lina M Obeid

series ordinal

2

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language of work or name

English

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publication date

February 2008

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published in

Nature Reviews Molecular Cell Biology

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volume

9

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issue

2

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page(s)

139-50

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cites work

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

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Resolution of inflammation: the beginning programs the end

31 March 2020

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Effects of sphingosine and other sphingolipids on protein kinase C

31 March 2020

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Programmed cell death induced by ceramide

31 March 2020

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Role of ceramide in cellular senescence

31 March 2020

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Physiological and pathological actions of sphingosine 1-phosphate.

31 March 2020

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Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

31 March 2020

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Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells

31 March 2020

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Ceramide 1-phosphate, a mediator of phagocytosis

31 March 2020

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Glycosphingolipids and drug resistance.

31 March 2020

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The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

31 March 2020

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When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

31 March 2020

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Further characterization of rat dihydroceramide desaturase: tissue distribution, subcellular localization, and substrate specificity

31 March 2020

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Substrate specificity of human ceramide kinase

31 March 2020

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Glycosphingolipidoses: beyond the enzymatic defect

31 March 2020

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The multigenic sphingomyelin synthase family

31 March 2020

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Traveling for the glycosphingolipid path

31 March 2020

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Glucosylceramide synthase and glycosphingolipid synthesis

31 March 2020

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Acid and neutral sphingomyelinases: roles and mechanisms of regulation

31 March 2020

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Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

31 March 2020

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Identification of a novel amidase motif in neutral ceramidase

31 March 2020

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Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

31 March 2020

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Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

31 March 2020

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Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer

31 March 2020

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Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions

31 March 2020

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Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren

31 March 2020

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Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

31 March 2020

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Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry

31 March 2020

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Characterization of sphingomyelinase activity released by thrombin-stimulated platelets

31 March 2020

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Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

31 March 2020

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Rapid transbilayer movement of ceramides in phospholipid vesicles and in human erythrocytes

31 March 2020

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Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets

31 March 2020

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Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

31 March 2020

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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

31 March 2020

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Lysophospholipids--receptor revelations

31 March 2020

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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

31 March 2020

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Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

31 March 2020

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Molecular machinery for non-vesicular trafficking of ceramide

31 March 2020

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Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein

31 March 2020

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The structural requirements for ceramide activation of serine-threonine protein phosphatases

31 March 2020

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Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

31 March 2020

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Ceramide inactivates cellular protein kinase Calpha

31 March 2020

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Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

31 March 2020

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PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

31 March 2020

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Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest

31 March 2020

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Kinase suppressor of Ras is ceramide-activated protein kinase

31 March 2020

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

31 March 2020

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Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

31 March 2020

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Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

31 March 2020

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Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

31 March 2020

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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

31 March 2020

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BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome

31 March 2020

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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

31 March 2020

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Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway

31 March 2020

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Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.

31 March 2020

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Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

31 March 2020

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Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae

31 March 2020

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Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast

31 March 2020

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Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae

31 March 2020

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Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

31 March 2020

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

31 March 2020

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Caspase-dependent and -independent activation of acid sphingomyelinase signaling

31 March 2020

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Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.

31 March 2020

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Tumor response to radiotherapy regulated by endothelial cell apoptosis

31 March 2020

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A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

31 March 2020

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Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms

31 March 2020

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Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.

31 March 2020

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Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation

31 March 2020

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Role of acidic sphingomyelinase in Fas/CD95-mediated cell death.

31 March 2020

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Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation

31 March 2020

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Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells

31 March 2020

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Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway

31 March 2020

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The extended family of neutral sphingomyelinases

31 March 2020

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Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase

31 March 2020

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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

31 March 2020

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A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse

31 March 2020

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Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression

31 March 2020

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Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation

31 March 2020

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Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium

31 March 2020

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Aging in rat causes hepatic hyperresposiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2.

31 March 2020

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Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.

31 March 2020

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Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

31 March 2020

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Amyloid-beta peptide enhances tumor necrosis factor-alpha-induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes

31 March 2020

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cca1 is required for formation of growth-arrested confluent monolayer of rat 3Y1 cells

31 March 2020

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Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells

31 March 2020

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Analysis of membrane topology of neutral sphingomyelinase 2

31 March 2020

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Sphingosine-1-phosphate: an enigmatic signalling lipid

31 March 2020

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PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

31 March 2020

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FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking

31 March 2020

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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

31 March 2020

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Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy

31 March 2020

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Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

31 March 2020

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Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators

31 March 2020

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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

31 March 2020

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

31 March 2020

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Essential role for sphingosine kinases in neural and vascular development

31 March 2020

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Sphingosine-1-phosphate signaling in the cardiovascular system

31 March 2020

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Egress: a receptor-regulated step in lymphocyte trafficking

31 March 2020

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New immunosuppressants with potential implication in multiple sclerosis

31 March 2020

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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

31 March 2020

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Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

31 March 2020

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Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor

31 March 2020

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Ceramide 1-phosphate/ceramide, a switch between life and death.

31 March 2020

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The CLN9 protein, a regulator of dihydroceramide synthase.

31 March 2020

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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

31 March 2020

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Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

31 March 2020

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Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development

31 March 2020

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Translational aspects of sphingolipid metabolism

31 March 2020

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Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria

31 March 2020

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Ceramides in insulin resistance and lipotoxicity

31 March 2020

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The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function

31 March 2020

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Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

31 March 2020

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Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

31 March 2020

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