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Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
main subject
ceramides
1 reference
based on heuristic
inferred from title
author name string
Norman S Radin
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
language of work or name
English
0 references
publication date
1 May 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
published in
Bioorganic & Medicinal Chemistry
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
volume
11
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
page(s)
2123-2142
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
issue
10
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
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Sphingolipids
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Advances in the signal transduction of ceramide and related sphingolipids
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Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology
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Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione
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Positive feedback control of neutral sphingomyelinase activity by ceramide.
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Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
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Effects of reduced and oxidized glutathione on sphingomyelinase activity and contents of sphingomyelin and lipid peroxidation products in murine liver
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Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells
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Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
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Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase
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Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
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Accumulation of glucosylceramides in multidrug-resistant cancer cells
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Lactosylceramide mediates shear-induced endothelial superoxide production and intercellular adhesion molecule-1 expression
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Sphingolipids in atherosclerosis and vascular biology
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Gangliosides shed by tumor cells enhance tumor formation in mice
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Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells.
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Dietary sphingolipids in colorectal cancer prevention.
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7 January 2021
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inferred from DOI database lookup
Tamoxifen retards glycosphingolipid metabolism in human cancer cells
1 reference
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Crossref
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7 January 2021
based on heuristic
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cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons
1 reference
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Crossref
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7 January 2021
based on heuristic
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Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species
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Crossref
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7 January 2021
based on heuristic
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Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
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Crossref
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7 January 2021
based on heuristic
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Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
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Oxidative stress: role of mitochondria and protection by glutathione.
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Molecular cloning and characterization of a human mitochondrial ceramidase
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Human acid ceramidase is overexpressed but not mutated in prostate cancer
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Crossref
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inferred from DOI database lookup
Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide
1 reference
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Crossref
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Differential insulin-like growth factor (IGF)-independent interactions of IGF binding protein-3 and IGF binding protein-5 on apoptosis in human breast cancer cells. Involvement of the mitochondria.
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Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation
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GD3 recruits reactive oxygen species to induce cell proliferation and apoptosis in human aortic smooth muscle cells
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptotic death by ceramide: will the real killer please stand up?
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
A new procedure for synthesis of 3-keto derivatives of sphingolipids and its application for study of fatty acid composition of brain ceramides and cerebrosides containing dihydrosphingosine of sphingosine.
1 reference
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7 January 2021
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1 reference
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7 January 2021
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Enantioselective depletion of mitochondrial glutathione concentrations by (S)- and (R)-3-hydroxy-4-pentenoate
1 reference
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Crossref
reference URL
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7 January 2021
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Glutathionyl transferase catalyzed addition of glutathione to COMC: a new hypothesis for antitumor activity
1 reference
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Crossref
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthetic phytoceramides induce apoptosis with higher potency than ceramides.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptotic DNA fragmentation and cell death by natural ceramide
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid
1 reference
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Crossref
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7 January 2021
based on heuristic
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Metabolic effects of short-chain ceramide and glucosylceramide on sphingolipids and protein kinase C.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis of new trans double-bond sphingolipid analogues: Delta(4,6) and Delta(6) ceramides
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7 January 2021
based on heuristic
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Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.
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7 January 2021
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7 January 2021
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A novel approach towards studying non-genotoxic enediynes as potential anticancer therapeutics.
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7 January 2021
based on heuristic
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Glucosphingolipids as sites of action in the chemotherapy of cancer
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chemotherapy by slowing glucosphingolipid synthesis
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of phospholipase C-gamma activity by glycosphingolipids
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7 January 2021
based on heuristic
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Improved inhibitors of glucosylceramide synthase
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7 January 2021
based on heuristic
inferred from DOI database lookup
Glycosphingolipid depletion in fabry disease lymphoblasts with potent inhibitors of glucosylceramide synthase
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7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of Gaucher disease with an enzyme inhibitor
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7 January 2021
based on heuristic
inferred from DOI database lookup
The relationship between the structure of the headgroup of sphingolipids and their ability to form complex high axial ratio microstructures
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Continuous and highly variable rate controlled release of model drugs from sphingolipid-based complex high axial ratio microstructures.
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7 January 2021
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Stimulation in vitro of galactocerebroside galactosidase by N-decanoyl 2-amino-2-methylpropanol
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7 January 2021
based on heuristic
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Synthetic inhibitors of galactocerebroside biosynthesis.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synthetic inhibitors of glucocerebroside β-glucosidase
1 reference
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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Glycosyltransferases of rat brain that make cerebrosides: substrate specificity, inhibitors, and abnormal products
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Crossref
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7 January 2021
based on heuristic
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Short chain ceramides as substrates for glucocerebroside synthetase. Differences between liver and brain enzymes
1 reference
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Crossref
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7 January 2021
based on heuristic
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Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain
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Crossref
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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of mitogenesis by kinins in arterial smooth muscle cells
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7 January 2021
based on heuristic
inferred from DOI database lookup
Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.
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7 January 2021
based on heuristic
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Doxorubicin-induced persistent oxidative stress to cardiac myocytes.
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells
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Crossref
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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of UDP-glucose:ceramide glucosyltransferase-1 by ceramide
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
CMT-3, a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer
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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling
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Crossref
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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells
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7 January 2021
based on heuristic
inferred from DOI database lookup
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol
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7 January 2021
based on heuristic
inferred from DOI database lookup
Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor.
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7 January 2021
based on heuristic
inferred from DOI database lookup
Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of delta 9-tetrahydrocannabinol by cytochrome P450 isozymes purified from hepatic microsomes of monkeys
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis by arachidonic acid in human retinoblastoma Y79 cells: involvement of oxidative stress.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and pharmacology of a hybrid cannabinoid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased basal glucose production in type 1 Gaucher's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential effects of enzyme supplementation therapy on manifestations of type 1 Gaucher disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clinical use of selective estrogen receptor modulators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective estrogen receptor modulation: the search for an ideal hormonal therapy for breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lactosylceramide is essential for the osteoclastogenesis mediated by macrophage-colony-stimulating factor and receptor activator of nuclear factor-kappa B ligand.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
1 alpha,25-dihydroxyvitamin D3 increases TGF beta 1 binding to human osteoblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functions of 1alpha,25-dihydroxyvitamin D(3) in mammary gland: from normal development to breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dexamethasone modulates rat renal brush border membrane phosphate transporter mRNA and protein abundance and glycosphingolipid composition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ipso-substitution by cytochrome P450 with conversion of p-hydroxybenzene derivatives to hydroquinone: evidence for hydroperoxo-iron as the active oxygen species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunochemical visualization and identification of rat liver proteins adducted by 2,6-di-tert-butyl-4-methylphenol (BHT)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of a new endogenous vitamin A metabolite
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of neutral sphingomyelinase participates in ethanol-induced apoptosis in Hep G2 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preneoplastic prostate lesions: an opportunity for prostate cancer prevention
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900609-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0968-0896(02)00609-0
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
PubMed ID
12713822
1 reference
stated in
Europe PubMed Central
PubMed ID
12713822
retrieved
6 August 2017
ResearchGate publication ID
10788183
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