(Q43682235)

English

The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway

scientific article published in July 2001

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scholarly article

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Europe PubMed Central

25 November 2017

The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway (English)

1 reference

Europe PubMed Central

25 November 2017

1 reference

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author name string

Decker RH

1

1 reference

Europe PubMed Central

25 November 2017

Dai Y

2

1 reference

Europe PubMed Central

25 November 2017

Grant S

3

1 reference

Europe PubMed Central

25 November 2017

publication date

1 July 2001

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Europe PubMed Central

25 November 2017

Cell Death & Differentiation

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Europe PubMed Central

25 November 2017

8

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Europe PubMed Central

25 November 2017

715-724

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Europe PubMed Central

25 November 2017

7

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Europe PubMed Central

25 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400868

0 references

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

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Death receptors: signaling and modulation

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Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

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Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1 reference

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

1 reference

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Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

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Cyclin-dependent kinases: engines, clocks, and microprocessors

1 reference

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Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

1 reference

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Preclinical and clinical development of cyclin-dependent kinase modulators

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Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

1 reference

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Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release.

1 reference

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

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Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

1 reference

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BID: a novel BH3 domain-only death agonist

1 reference

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Target protease specificity of the viral serpin CrmA. Analysis of five caspases

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Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

1 reference

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway

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Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

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Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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Apoptosis in the absence of cytochrome c accumulation in the cytosol.

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Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells.

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Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

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p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

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Establishment and characterization of a human histiocytic lymphoma cell line (U-937)

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Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

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Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage

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Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells

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Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.

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Simultaneous release of adenylate kinase and cytochrome c in cell death

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10.1038/SJ.CDD.4400868

1 reference

Europe PubMed Central

25 November 2017

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https://api.fatcat.wiki/v0/release/hvbb6hz7u5fbra7rbgm4f6zkcu

24 November 2022

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mapped directly with Wikidata item

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25 November 2017

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