(Q24294788)

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Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis

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Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis (English)

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apoptotic process

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Alkaline ceramidase 3

1 reference

GOA release 2020-03-11

dihydroceramidase activity

1 reference

GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

author name string

Wei Hu

1

author given names

Wei

author last names

Hu

1 reference

PubMed publication ID

20 October 2023

Ruijuan Xu

2

author given names

Ruijuan

author last names

Xu

1 reference

PubMed publication ID

20 October 2023

Wei Sun

3

author given names

Wei

author last names

Sun

1 reference

PubMed publication ID

20 October 2023

Zdzislaw M Szulc

4

author given names

Zdzislaw M

author last names

Szulc

1 reference

PubMed publication ID

20 October 2023

Jacek Bielawski

5

author given names

Jacek

author last names

Bielawski

1 reference

PubMed publication ID

20 October 2023

Lina M Obeid

6

author given names

Lina M

author last names

Obeid

1 reference

PubMed publication ID

20 October 2023

Cungui Mao

7

author given names

Cungui

author last names

Mao

1 reference

PubMed publication ID

20 October 2023

language of work or name

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publication date

12 March 2010

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Journal of Biological Chemistry

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285

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11

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7964-76

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Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Molecular cloning and characterization of a human mitochondrial ceramidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Molecular cloning and functional characterization of murine sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

19 March 2017

Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Docosahexaenoic acid domains: the ultimate non-raft membrane domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Autocrine and paracrine roles of sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Farber disease: clinical presentation, pathogenesis and a new approach to treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Sphingosine in apoptosis signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Processing of gene expression data generated by quantitative real-time RT-PCR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Ceramidases in the regulation of ceramide levels and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Activation of a nuclear sphingomyelinase in radiation-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

27 September 2017

Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

30 May 2018

Ceramides and Sphingomyelins with High Proportions of Very Long-chain Polyunsaturated Fatty acids in Mammalian Germ Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

29 November 2018

Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

29 November 2018

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

29 November 2018

Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832947

29 November 2018

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20068046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20068046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of free sphingosine in liver by high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/20068046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities of lysosomes in human diploid fibroblasts from patients with Farber's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20068046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20068046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.063586

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release_usuiysqzxzekxlmy4s2grrua64

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PubMed publication ID

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